Chem Basis PPIs 3

The flashcards below were created by user kyleannkelsey on FreezingBlue Flashcards.

  1. Image Upload 1
    What effect does the ether oxygen have on this molecule?
    Donates electrons through the pi system to ↑ nucleophilic character of the pyridine N (Lansoprazole)
  2. Image Upload 2
    What effect do the three fluorine atoms have on Lansoprazole?
    Exhibit electronic pull and give protection against metabolism
  3. Image Upload 3
    What effect does the methyl group have on this molecule?
    Pushes electrons toward the pyridine N through the sigma bonds (Lansoprazole)
  4. Image Upload 4
    How does the onset of action of Lansoprazole compare to Omeprazole and Rabeprazole?
  5. Image Upload 5
    What CYP enzymes metabolize this drug?
    2C19 and 3A4 (Lansoprazole)
  6. Image Upload 6
    What changes to this molecule does CYP2C19 cause?
    Hydroxylation of the benzimidazole C5 (Lansoprazole)
  7. Image Upload 7
    What clinical DDIs are associated with Lansoprazole?
    None, can competitively inhibit 2C19 and induce 1A’s, but no evidence of interactions
Card Set
Chem Basis PPIs 3
Chem Basis PPIs 3
Show Answers