Pharmacology Final

The study of drugs and their interactions with living systems

The study of drugs in humans

The use of drugs to diagnose, prevent, or treat disease or prevent pregnancy

• Administration
• Pharmacokinetics
• Pharmacodynamics
• Individual Variations

• Route
• Timing
• Dosage

• Absorption
• Distribution
• Metabolism
• Excretion

• lipid soluable
• or
• direct transport mechanism

• Inactivate a drug
• Increase the therapeutic action
• Activate prodrugs
• Accelerate renal excretion
• Increase or decrease toxicity

largest dose that a drug can elicit regardless of dose

Agonist-molecules that activate receptors-mimic the action of endogenous molecules

Antagonist-prevents receptor activation

•   Competitive-binds reversibly by highest
•   concentration

  Noncompetitive-binds irreversibly

• Partial agonist- (partial antagonist) - achieves less than the effect of an agonist,
• but can compete for agonist sites

minimal effective concentration, will have no effect below this

Lethal Dose / Effective Dose

Means it is safer

The impact of a drug at the site of action

entering the system