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Mundi
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Somatropin (Nutropin) - safety
- Growth hormone
- - ↑ metabolic rate, O consumption, RR, HR, growth, maturation
- Safety: thyroid function, BG test, GTT, GH antibodies
- Long bones closure
- medication clearance
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Graves' disease
Hyperthyroidism
S/S: ↑ body temp, tachycardia, thin skin, palpitations, HTN, flushing, intol to heat, amenorrhea, weight loss, goiter
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Proplythiouracil
Treats hyperthyroidism
MOA: Thioamides prevent formation of thyroid hormone within the thyroid cells; ↓ serum level of thyroid hormone; partially inhibit T4-T3 hormone
AE: Skin reactions, vertigo, drowsy, arthralgia, myalgia, *thyroid suppression effects
D2D: oral anticoagulants, theophyline, metoptolol, propranolol, digitalis
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Iodine Solutions
Treats hyperthyroidism
MOA: thyroid cells becomes oversaturated w/ iodine ions & stop prod thyroid hormone
USES: presurg suppress of thyroid; acute thyrotoxicosis; adjunct therapy for hyperthyroidism; thyroid blocking in radiation emergency
AE: metallic & burning in mouth, sore teeth & gums, stained teeth, skin rash, hypothyroidism
D2D: anticoagulants, theophylline, digoxin, metoprolol, propranolol
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Levothyroxine (Synthroid)
treats hypothyroidism
AE: skin reaction, hyperthyroidism symp., cardiac stim, CNS effects
Caution: hypoadrenal conditions (Addison's), lactation
D2D: cholestyramine, oral anticoagulants, theophylline, digitalis
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AC1 - Goal/Normal range
ADA goal: ≤ 7%
- AACE goal: ≤ 6.5%
- normal: 3.8-6.5%
- Noncritically ill: premeal 140; random 180
- Critically ill: 140-180 mg/dL
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Insulin: rapid, short, intermediate, long-acting
- Rapid: Lispro/asport/glulisine
- Short: regular
- Intermediate: NPH
- Long-acting: glargine/detemir
- Adjust dose based on:
- -fingerstick
- -carb intake
- -fasting blood glucose
- -anticipated activity
- Advantage of rapid-acting:
- ↓ risk of hypoglycemia
equal A1C lowering in type 1
Draw Regular before NPH (clear before cloudy)
Pt Teaching:
Absorption rates:
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