microbio notes 1 Nov. 26 part 2 (adaptive immunity T cells B cells lymphatic system macrophages

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Can multiple B cell clones recognize a single antigen?

yes, if the antigen contains many epitopes
an immunoglobin molecule contains _ polypeptide chains

4
an immunoglobin molecule contains 2 __ ____ and 2 ___ _____

2 light chains and two heavy chains
Each polypeptide chain of the immunoglobin molecule contains a ____ region and a _____ region

variable and constant
"__ ___" part of the antibody is susceptible to protease activity

the hinge
When "the hinge" is broken by a protease, the antibody is broken in to ___ and __ regions

Fab and Fc regions
the variable region of a polypeptide component of an antibody is coded by what genes?

it is coded by a combination between a variable exon and a J exon
what do rag proteins do?

they conduct the random splicing of V and J genes
does alternative RNA splicing also take place during the synthesis of the polypeptides necesssary for antibodies?

yes and this adds to the variation
Which provides more variety, light chains or heavy chains?

heavy chains
what is the mechanism by which antibody structure is varied on the DNA level called?

combinatorial joining
what is the protein complex that antigen presentation depends on?

MHC
MHC I is located on which cells?

all cells except for RBC
MHC II is located on which cells?

macrophages, dendrtic cells, and clonally selected cells
do MHC I and II differ in function?

no, but they have different structures
MCH II is derived from what?

the phagosome

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microbio notes 1 Nov. 26 part 2 (adaptive immunity T cells B cells lymphatic system macrophages

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microbio notes 1 Nov. 26 part 2 (adaptive immunity, T cells, B cells, lymphatic system, macrophages, cytokine, epitope, multivalent antibody, variable region, antigen presentation, MHC)

Updated

2013-11-26T18:20:15Z

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