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What is penicillin class?
Beta lactams
What does penicillin cover?
often gram +
What is the spectrum of Augmentin? (a penicillin)
Gram +
Some gram -
Anaerobes like bacteroids
What is augmenting the drug of choice for?
Animal bites (pasturella multocida)
Augmentin is a great 1st line of defense against what?
Mild Diabetic foot infections
PO
What is Unasyn (a penicillin-- ampicillin/sulbactam) the drug of choice for?
presume aerobi and anaerobic infections
What is the spectrum fro Zosyn?
Gram +
Increased gram- coverage
anaerobes
What is the most common broad spectrum IV drug used in diabetic infections today?
Zosyn ( Pipercillin/Tazobactam)
What is the spectrum of Penicillin G?
Pure streptococcal infections
anaerobes including clostridia (no bactericidal coverage)
Enterococcus
What is Penicillin G used to treat?
open farm/soil injuries
drug addition
What class are
cephalosporins?
Beta lactamase inhibitors
through
PCN binding protein
What is an important fact about cephalosporins in relation to patient allergies?
10 % if patients with allergic hypersensitivity to PNC also have cx-rxn with cephalosporins
What is the spectrum for cephalosporins?
Staph
Strep
Gram -
anaerobes other than bacteroides
What gram negatives are treated with cephalosporins? (4)
E. Coli
Shigella
Salmonella
P. mirabilis
What is Keflex (Cephalexin) used to treat as a 1st line of defense?
Superficial infections in healthy patients
Ex
: cellulitis, ingrown nails
Ancef/Kefzol
Great Bone penetration
with
long half life
(surgical prophylaxis)
What are aminoglycosides?
protein synthesis inhibitors
bind to 30s and 50 s ribosomal subunit
administered IV or IM only
What are adverse effects of amino glycosides?
Ototoxic!
Nephrotoxic!
What is the spectrum of gentamicin? (amino glycoside)
Aeorbic gram negatives
stap
strep
NO ANAEROBIC COVERAGE
When does gentamycin peak/tough?
peak= following administration
trough= 20-30 mins prior to nect does
What do you monitor with gentamycin?
serum creatine
What does clindamycin do?
inhibit protein biosynthesis via 50s ribosome
What is the spectrum of Clindamycin?
Gram+
Anaerobes
Does Clindamycin cover C. diff?
NO
Describe the metabolism of Clinamycin
By the liver
good agisnt some strains of MRSA
What is an adverse effect of clindamycin?
C. difficile
What is Clindamycin prescribed for?
open fractures only with a PCN allergy
What is the spectrum fro Vancomycin?
ALL GRAM +
MRSA
MRSE
Enterococcus
gram + anaerobes like clostridia, corynebacteria
NO gram -
What is an adverse effect go Vancomycin?
Red Man syndrome
Nephrotoxicity
ototoxic
When can oral vancomycin be given?
ONLY for pseudomembranous colitis after flagyl fails
What is Vancomycin used in conjunction with? for what?
with
Zosyn
for IV Abx coverage in
diabetic infections for coverage of MRSA
What is the spectrum of Zyvox?
ALL GRAM +
including ENTEROCOCCUS and MRSA
what is the bioavailibility of Zyvox and why does that matter?
100% bioavailble = only IV for those who cannot tolerate PO
Adverse effects of Zyvix (5)
Throbocytopenia
Neutropenia
Pancytopenia
Neuritis
Peripheral neuropathy (only in prolonged >3mo use)
Author
xbecx10
ID
248704
Card Set
Antibiotics
Description
Dr. Moore Intro to Surgery
Updated
2013-11-24T19:08:35Z
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