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tissues can tolerate dehydration as much as
70%
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osmolytes
substances that increase intercellular osmolarity; urea and trimethylamine oxide
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obligatory osmotic exchange
occur in response to physical factors over which animals have no control
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regulated osmotic exchanges
physiologically controlled serve to maintain internal homeostasis
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arginine vasotoxcin (AVT)
controls permeability of amphibian skin
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countercurrent multiplication
utilized in kidneys of birds and mammals to produce hyperosmotic urine which is more concentrated than the blood plasma
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loop of henle
hairpin like bend in kidney tubule, allows birds and mammals to exploit dry enviroments
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eurhaline
can tolerate a wide range of salinites
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stenohaline
can tolerate on a narrow osmotic range
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freshwater animals are usually
hyperosmotic to their environment in the range of 200-300 mosm L-1. 1. subject to swelling 2. subject to loss of body salts
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chloride cells
mediate transport of NaCl from the blood into the surrounding water
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human kidney can remove __ of Na + from the bloodstream per liter of urine produced
6 g
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cortex
outer layer of the kidney
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medulla
inner layer of the kidney, sends papillae into renal pelvis
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kidney anAtomy
renal pelvis goes to ureter that empties into urinary bladder. and micturition via the urethra
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release of urine is accomplished by
simultaneous contraction of the smooth muscle of the bladder wall and relaxation of the skeletal muscle sphincter around the opening of the bladder. as the bladder is stretched by filling, stretch receptors in the wall generate nerve impulses.
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nephron
- functional unit of the kidney, intricate epithelial tube
- 80% cortical Nephron
- 20% juxtamedullary Nephron
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collecting ducts
each kidney contains numerous nephrons which empty into __
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collecting ducts combine to form
papillary ducts which empty into the renal pelvis
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glomerulus
formed from tuft of capillaries inside bowman;s capsule. responsible for the first step in urine formation
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vertebrates that lack the loop of henle are
incapable of producing urine that is hyperosmotic to the blood
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juxtamedullary nephrons
have their glomeruli in the inner part of the cortex and long loops of henle that plunge deeply into the medulla
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cortical nephrons
their glomeruli in the outer cortex and short loops of henle extend a short distance into the medulla
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processes that contribute to composition of urine
- -filtration of blood plasma to form ultrafiltrate in lumen of bowman's capsule
- -tubular reabsorption of approx 99% of water and most salts from the ultrafiltrate, left behind conc waste product
- -tubular secretion of number of substances, in nearly all instances via active transport
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glomerular ultrafiltrate contain
all of blood expect blood cells and blood protein. filtration 15-20% of water and solutes are removed
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process of ultrafiltration in glomerulus depends on
- -net hydrostatic pressure difference between the lumen of the glomerular capillaries and the lumen of bowman's capsule
- -colloid osmotic pressure of blood plasma
- hydraulic permeability of 3-layered tissue separating the two compartments
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fenestrated capillaries
makes up the glomerulus, contains large pores that are 100x more permeable than the capilaries found in the body
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problems of osmoregulation
- 1. extensive cellular dehydration results in impairment of metabolism
- 2. changes in ion composition of extracellular fluid results in malfunctions of failure of electrical mechanisms (AP mech in all cells;synaptic mech in neural tissues)
- 3. changes in pH affect all proteins and functions of all protein related mechs
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marine invertebrates have extracellular fluids
similar to sea water
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vertebrate extracelluar ionic conc are about
1/3 that of sea water (reflects freshwater origin of most vertebrates)
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urinary systems
most important system involved in the regulation of extra cellular fluid and excretion of nitrogenous waste
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functions of urinary system
- removal of soluble metabolic wastes
- regulation of composition of blood including blood volume
- homeostasis of extracellular fluid
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forms of nitrogen excretion
- 1urea- 2N terrestrial vertebrates (ureotelic)
- ammonia 1N aquatic animals(teleosts) (ammonotelic)
- uric avid 4N birds and land reptiles (uricotelic)
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ammonia
- formed by catabolism of amino acids
- ammonia is toxic
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ammonia is salaved
- 1.via glutamate reaction (ammonia + glutamate >>glutamine)
- 2. some must excreted
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Marine birds
- sea water urine nasal fluid
- 3% 3% 5%
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Humans
- sea water urine nasal fluid
- 3% 2% 1%
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organs of system
2 kidneys, 2 ureters, 1 urinary bladder, 1 urethra
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peritoneum
serous (highly vascularized), membrane of connective tissue, inside of abdominal walls and reflected over certain viscera
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mesentary
double layered peritoneal fold connecting intestines to posteror abdominal wall
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interior anatomy
cortex, medulla renal columns, pelvis
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functions of the kidney
- 1. homeostasis of tissue fluids
- a. excretion of nitrogen waste
- b. maintenance of fluid volume (blood)
- c. maintenance of fluid composition
- d. assists in maintaining pH
- 2. endocrine function (hormones)
- a. makes erythroporetin (production of red blood cells in bone marrow)
- b. makes renin
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substructures of kidney
- 1 renal corpuscle contains glomerulus in bowman's capsule
- 2. proximal convoluted tubule
- 3. loop of henle
- 4. distal convoluted tubule
- 5. collecting duct
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mechanisms of the substructures of kidney
- 1. filtration-bowman's capsule
- 2.reabsorbtion- proximal convoluted tubule 75% and distal convoluted tubule
- 3.secretion/synthesis - distal convoluted tubule
- 4. final concentration- collecting duct
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