dmrn1007

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defense factors
- mucus
- bicarbonate
- blood flow
- prostaglandins
aggressive factors
- NSAIDs
- smoking
- H. Pyloris
- pepsin
- gastric acid
prostaglandins

suppress secretion of gastric acid
helicobacter pylori (H. pylori)

gram negative bacteria that colonize in stomach and duodenum
zollinger-ellison syndrome

tumor causes hypersecretion of gastric acid alone without bicarbonate
3 test to evaluate h.pylori eradication
- serology
- breath
- biopsy
- stool
rantidine hydrochloride (Zantac)
- H2RA
- ADR
- decrease libido
- impotence
- CNS effects
- INTER
- warfarin
- phenytoin
- antacids
omeprazole (prilosec)
- protein pump inhibitor (PPI)
- ADR
- none long term
- long term cancer
- INTER
- ampicillin
- digoxin
- iron
- ketoconazole
sucralfate

viscous substance that stick to ulcer for up to 6 hours
sucralfate (carafate)
- ADR
- constipation
- INTER
- warfarin
- phenytoin
- digoxin
- ciprofloxacin
- antacids
aluminum hydroxide gel (amphogel)
- antacid
- ADR
- NA+ containing antacid
- aluminum hydroxide
- magnesium compounds
- INTER
- warfarin
- tetracycline
misoprostol (cytotec)
- pregnancy risk X
- ADR
- dysmenorrhea
- spotting
- diarrhea
- abdominal pain
laxative
- used to ease or stimulate defacation
- produce soft stool over a day or more
catharsis

prompt fluid evacuation of the bowel
bulk forming laxative
psyllium (metamucil)
- soften stool
- increase bulk of stool
- like dietary fiber
- group III
surfactant laxative
ducosate (colace)
- lower surface tension of stool to allow penetration of water
- group III
stimulant laxatives
bisacodyl (dulcolax)
- simulate intestinal peristalsis
- increase water and electrolytes in intestinal lumen
- PO or rectal
- group II
osmotic laxatives
magnesium hydroxide
(milk of magnesia)
- draw water into intestines to incease bulk of stool
- group I
proctitis

inflammation of lining of rectum
Group I laxatives

2-6 hr
Group II laxative

6-12 hrs
group III laxatives

1-3 days
bisacodyl
- rectal act in 15 min
- group I
esophageal obstruction
- when you dont drink enough water with medicine
- 8 oz
intestinal obstruction

if passage through intestines is arrested
antiemetic receptor
- 5ht3 serotonin
- da2 dopamine 2
- m muscarinic cholerginic
- h1 histamin 1
- nk1 neurokinin 1
antiemetic

given to supress nasea and vomiting
ondansetron (zofran)
- blocks 5ht3 receptor located in ctz and
- on afferent vagal neurons in GI tract
- po or iv
- ADR
- headache
- dizziness
- diarrhea
- INTER
prochloperazine (compazine)
- blocks da2 receptors
- ADR
- hypotension
- anticholinergic
- eps
- sedation
dexamethasone (decadron)

glucocorticoid
dronabinol (marinol)
- marijuana
- ADR
- dissociation
- hypotension
- dysphoria
- tachycardia
scopolamine (transderm scop)
- muscarinic antagonist
- ADR
- anticholinergic effects
- sedation
dimenhydrinate (Dramimine)
antihistamine
- blocks h1 and muscarinic receptors
- ADR
- sedation
- anticholinergic effects
drug interaction for antiemetics
- CNS depressants
- antihypertensives
- anticholinergic medications
diarrhea
- stools of excessive volume and fluidity
- increased frequency of defacation
diphenoxylate (lomotil)
- opiod used for diarrhea
- activiate opiod receptors in the GI tract to decrease intestinal motility
metoclopramide (reglan)
- prokinetic agents
- ADR
- eps
- sedation
- diarrhea
- INTER
- pt with seizures
prokinetic agent

block da2 and 5ht3 in CTZ
h2ra suffix

-dine
proton pump inhibitors (ppi)
suffix

-azole

Author

blkbunny20

24799

Card Set

dmrn1007

Description

digestive system drugs

Updated

2010-06-27T19:08:34Z

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