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Functions of Skeleton
Support, protection, movement, electrolyte balance, acid base balance, and blood formation
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Hardening process of bone
Calcification
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Cranial bones, sternum, scapula, ribs, and hip bones are all:
Flat Bones
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Humerus, radius, ulna, femur, fibula, tibia, metacarpals, metatarsals, and phalanges are:
Long Bones
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Carpal, atrial, and patella are:
Short Bones
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Vertebrae bones are called:
Irregular Bones
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Contains bone marrow
Marrow Cavity
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Shaft of long bone is called
Diaphysis
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Heads of long bone are called:
Epiphysis
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Joint surface where one bone meets another covered with a layer of Hyaline cartilage is called:
Articular cartilage
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Bone is covered with a sheath called:
Periosteum
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Growth plate is called
Epiphyseal plate
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Two layers of compact bone with spongy middle layer is called
Diploe
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Bone forming cells
Osteoblasts
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Former osteoblasts
Osteocytes
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Stimulates insulin secretion by pancreas, increases sensitivity in adipocytes, and limits growth of adipose tissue
Osteocalcin
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Bone dissolving cells that develop from blood cells
Osteoclasts
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Osteoblasts secrete
Osteocalcin
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Inorganic calcium phosphate salt synthesized by osteoblasts
Hydroxyapatite
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Childhood disease from lack of calcium
Rickets
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Brittle bone disease "without collagen"
Osteogenesis imperfecta
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Calcified hard bone, sponge-like appearance
Spongy Bone
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Thin plates of spongy bone
Trabeculae
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Soft tissue of marrow cavity
Bone marrow
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Two types of bone marrow
Yellow and Red
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Marrow found in axial skeleton
Red Bone Marrow (myeloid tissue)
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Hemopoietic tissue (produces red blood cells)
Red bone marrow
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Fatty Marrow
Yellow Marrow
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Where is most red marrow found?
In children
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Where is most yellow marrow found?
In adults
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Formation of bone
Osteogenesis (ossification)
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Bone develops by two methods:
Intramembranous and endochondral ossification
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Produces flat bones of skull and most of clavicle
intramembranous
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Process in which bone is preceded by hyaline cartilage "model" that becomes replaced by osseous tissue; begins in fetal development and continues into 20's (most bones of body)
Endochondral ossification
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Two directions bones grow:
Length and width
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Growth in length:
Elongation
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Cartilage growth from within
interstitial growth
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Bone growth in width
Appositional growth
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Condition where long bones of limbs stop growing in childhood:
Acondroplastic dwarfism
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Condition where a deficiency of growth hormone stunts growth in all of bone
Pituitary dwarfism
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States that the architecture of a bone is determined by the mechanical stresses placed upon it, and the bone thereby adapts to withstand these stresses:
Wolfe's Law of Bone
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Bones are continually:
Remodeled
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Crystallization process in which calcium, phosphate, and other ions are taken from blood plasma and deposited in bone tissue
Mineral deposition
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Abnormal calcification
Ectopic ossification
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Adult body contains ____g of calcium, with ___% of it in the bones.
1,100; 99
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Calcium deficiency
Hypocalcemia
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Blood calcium in excess
Hypercalcemia
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Depends on a balance between dietary intake, urinary and fecal losses, and exchanges with the osseous tissue
Calcium Homeostasis
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Calcium Homeostasis is regulated by three hormones:
Calcitriol, calcitonin, and parathyroid horomone
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Form of vitamin D produced by the sequential action of the skin, liver, and kidneys
Calcitriol
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Softness of bone in children
Rickets
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Softness of bone in adults
Osteomalacia
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Most important factor in Blood Calcium Levels (bcl):
Parathyroid hormones
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Causes premature closure and results in abnormally short adult stature
Anabolic Steroids
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4 stages of healing fractures:
- 1. Hematoma
- 2. Formation of soft callus
- 3. Conversion to hard callus
- 4. Remodeling
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Most common bone disease (mostly in women)
Osteoporosis
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