Vesicles and Complexes

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  1. COPII
    • Mediate first leg of the biosynthetic pathway
    • Select and concentrate certain components for transport as long as they have an ER export signal as part of their cytosolic tail
    • -          Binds proteins that will function in later stages in the pathway, help docking and fusion, or can bind soluble particles
  2. COPII
    Contains a small Gprotein called Sar1, which plays a regulatory role by initiating vesicle formation and regulating the assembly of the vesicle coat
  3. COPI
    - function
    • Function in the retrograde transport of proteins , such as transà cis or ERGIC à ER
    • -          retaining or retrieval
  4. COPI
    - structure
    • Contains a membrane bending protein called Arf1
  5. TOM Complex
    Contains receptors that recognize and bind mitochondrial proteins and protein-lined channels through which unfolded polypeptides are translocated across the outer membrane
  6. TOM complex
  7. TIM complexes
  8. TIM complex 22
    Binds integral proteins of the IMM that contain an internal targeting sequence and inserts them into the lipid bilayer
  9. TIM complex 23
    Binds proteins with an N-terminal presequence, which includes all of the proteins of the matrix; it recognizes and translocates the matrix proteins completely through the IMM and into the inner aqueous compartment
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Vesicles and Complexes
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