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Structure of RER
- - ribosomes on the outside (form polysomes)
- - ER lumen
- - cisternae that may be attached to one another
- - continuous with the nuclear envelope
- - flattened sheets
- polarity from one end to the other
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Function of the RER
- - starting point of the biosynthetic pathway
- - synthesis of proteins, carbs, and phospholipids that will be destined for export from the cell or remain in other membrane compartments or in the membrane
- storage of antibodies
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Structure of the SER
- - interconnected tubules
- - no ribosomes on the outside
- - connected to RER (this connection allows for diffusion of proteins and lipids between one another)
- contains reticulons (responsible for curvature of SER tubules)
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Function of the SER
- - synthesis of phospholipids
- - synthesis of cholesterol and steroids
- - synthesis of glycolipids
- - storage of Calcium ions that leads to contraction upon release
- detoxification of alcohols by oxygenases
- synthesis of bile salts
- processing of glycogen
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Structure of the Golgi Apparatus
- - interconnected with space between them
- - three regions: cis, medial,and trans, as well as the CGN and TGN
- - contains different composition from cis to trans
- - flattened, dislike membranous cisternae with dilated rims and associated vesicles and tubules
- - curved cisternae: usually 3-7, but some have few or up to several thousand distinct stacks
- trans region is supported by a peripheral membrane skeleton made up of spectrin, ankyrin and actin
- - polar: different faces; 1/2 a micrometer in diameter; tubules around the outside
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Function of the Golgi Apparatus
- - processing plant (modification of proteins with addition of sulfates, phosphates, carbs, etc.)
- - assembly of carbohydrate component of glycoproteins and glycolipids
- synthesis of most of a cell’s complex polysaccharides
- - secretion
- membrane transformation
- origin of lysosomes
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Structure of peroxisome
very simple organelle with two subcompartments: boundary membrane and internal matrix
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Function of peroxisome
detox of alcohols
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Structure of mitochondria
four subcompartments: IMM, OMM, matrix, intermembrane space
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Function of mitochondria
- synthesize 10% of their own proteins, but not all
- cell resp
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Structure of Chloroplasts
- - six subcompartments:
- o thylakoid membrane
- o thylakoid space
- o stroma
- o outer membrane
- o inner membrane
- intermembrane space
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Function of chloroplasts
photosynthesis
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Types of proteins made on the RER
- secreted proteins, integral membrane proteins, and souble proteins that remain within compartments of the endomembrane system
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Types of proteins made in the cytosol
- proteins that will remain in the cytosl, peripheral proteins of the cytosolic surface, proteins destined to the nucleus, peroxisomes, chloroplasts, and mitochondria
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