pharm 4 allergy drugs

• 1st gen antihistamine
• -H1 antagonist
• -blocks histamine reseptors

PE= reduce flushing, edema, musoucs secretion, itching

• CNS= sedation
• **IN high doses--> CNS stimulation and seizures b/c histamine blocks seizure activity

• 2nd gen antihistamine
• -blocks receptors

pe= same as benadryl

cns= very little, is long acting

• 2nd gen antihist
• Nasal spray
• blocks hist receps

drowsiness and throat irritation

• cyclooxgenase (product of arach. acid production)
• the Good Cox
• -In ALL tissues

• protects against mucosa-increasing blood flow
• supports renal function
• promotes platelet aggregation

• gastric erosion
• renal impairment
• bleeding
• prevent MI/stroke

• Bad COX
• at site of injury
• mediates inflammation
• sensitizes pain receptors
• mediates fever and pain in brain
• supports renal function
• vasodilation
• promotes colon cancer

decrease pain, fever inflamm

• promote renal failure
• promote embolic events (MI)

• COX inhibitor
• Stop production of prostaglandins
• -suppress inflamm
• -relieve pain
• -reduce fever

• risk of:
• stomach ulcer
• bleeding
• renal impairment

• Aspirin
• NON-selective COX inhibitor
• Irreversible

• Suppress inflamm, analgesia, and platelets. Reduce fever, relief of dysmenorrhea, colorectal cancer preventtion, Alz's prevention
• Stroke and MI protection

SE: GI, bleed, RI, Reye's, ringing in ears

• Ibuprofen, Naproxan - po forms
• 1st gen COX 1 & 2 inhibitors
• Reversible

rheumatoid and osteoarthritis pain relief

SE: blding, GI, renal impairment, slight inc. in thrombotic events

• IV/IM version of NSAID
• -relieves surgical pain as well as opioid

2nd gen COX 2 inhibitor

• reduce pain, fever, and inflammation
• -W/O bleeding, renal failure, and GI problems associated with COX 1 inhibition

2nd most used drug in US

• Anti-pyretic and analgesic effects
• -No inflamm effects
• -Inhibits prostaglandin synthesis in CNS only

inhibits metabolism of Warfarin

Antidote for Acetaminophen overdose