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erythrocytes
red blood cells, remain in bloodstream
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leukocytes
white blood cells
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plasma
liquid portion of blood
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blood cells are formed in
bone marrow, sternum, vertebrae, pelvis, and ends of long bones in arms and legs
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hematopoiesis
developed blood cells to their mature form
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transports oxygen and CO2
erythrocytes
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erythropoiesis
RBCs decrease in size and develop hemoglobin
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hemoglobin
carries oxygen to body tissue and exchanges it for CO2
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RBCs live
about 120 days then rupture releasing hemoglobin and cell fragments
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leukocytes
- protect body from pathogens and foreign substances
- remove debris from injured tissue
- aid in healing process
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White blood cells migrate through
endothelial walls of capillaries and venules and enter tissue spaces.
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diapedesis
process how WBC migrate
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3 different types of granulocytes
- neutrophils
- eosinophils
- basophils
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agranulocytes
arise in bone marrow but mature in lymph tissues
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2 types of agrunulocytes (AKA mononuclear leukocytes)
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platelets (thrombocytes)
smallest formed elements found in blood.
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fibrinogen
soluble blood protein
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serum
fluid resulting from when fibrinogen and clotting elements are removed from plasma
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6 items the lymph system consists of
- lymph (fluid)
- lymph vessels
- nodes
- spleen
- thymus
- tonsils
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3 functions of lymph system
- maintaining fluid balance
- transporting lipids away from digestive organs
- filtering and removing unwanted or infectious products in lymph nodes
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lymph vessels begin as
closed ended capillaries in tissue spaces
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interstitial (tissue fluid)
fluid that seeps from blood capillaries and resembles plasma but contains less protein
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lymph capillaries
microscopic vessels
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right lymphatic duct
vessels from the right chest and arm join right lymphatic duct
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right subclavian vein
major vessel in cardiovascular system where the right lymphatic duct drains
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thoracic duct
lymph from all other areas of body enters here
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left subclavian vein
where the rest of the lymph drains after going through thoracic duct
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spleen
- resembles a lymph node
- acts as filter by removing cellular debris, bacteria, parasites and other infectious agents
- also destroys old RBCs and serves as respiratory for healthy blood cells
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thymus
- located in upper part of chest
- partially controls immune system by transforming lympohcytes into T cells to function in immune system
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tonsils
- masses of lymphatic tissue located in pharynx
- act as filters to protect upper respiratory structures from invasion by pathogens
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resistance
work together to protect against disease
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first line barriers
- keep pathogens from entering the body
- includes skin and mucous membranes, tears, saliva, and gastric secretions
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second line barriers
- protect body once pathogens have gained entry
- includes phagocytic cells and inflammation
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B cells
formed and mature in bone marrow then migrate to lymph system
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T cells
- formed in bone marrow but migrate to thymus where they mature before entering lymph system
- responsible for cellular immunity
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humoral immunity
protects against bacteria and viruses that have not yet entered a cell
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B cells produce
clone of cells called plasma cells
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plasma cells produce
highly specific proteins called antibodies
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cellular immunity
protects against viruses and cancer cells
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4 types of T cells
- cytotoxic
- helper
- suppressor
- memory
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cytotoxic T cell
- destroys invading antigen
- determines antigens weakness and uses weakness as point of attack
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helper T cell
- essential to proper functioning of humoral and cellular immunity
- uses cytokines to activate, direct and regulate activity of other components
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suppressor T cell
- monitors the progression of infections
- when infection resolves, T cell shuts down immune response
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memory T cell
find way to lymph system and remain their long after encounter with antigen, ready for combat if antigen reappears
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hematology
branch of medicine that studies blood cells, blood clotting mechanisms, bone marrow and lymph nodes
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allergy and immunology
branch of medicine involving disorders of the immune system
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