aspirin-induced anaphylactoid reactions are not immunological
incidence of hypersensitivity estimated at 10-25% in patients with asthma, nasal polyps, chronic urticaria
1% in healthy individuals. Aspirin intolerance is a contraindication to the use of any other NSAIDs
aspirin induced airway hyperreactivity in asthmatics, leading to bronchoconstriction, ocular and nasal congestion
- aspirin triad:
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- possible mechanism: inhibition of COX pathways shunts AA to LOX, resulting in increased formation of leukotrienes > cross-reactivity with NSAIDs