-
Corynebacterium diptheriae
Diphtheria toxin
- cytolysis (cell death); kills cells
- Adp ribosylation of elongation factor 2 results in the inhibition of protein synthesis.
-
Escherichia coli
Heat-labile enterotoxin
cytotoxin
Heat-stable enterotoxin
- Diarrhea
- Identical to cholera toxin
- Hemorrhagic colitis
- Identical in action to shiga toxin- adp ribosylation of adenylate cyclase results in its activation. this results in an increase in camp levels in a cell.
- Diarrhea
- Activates host guanylate cyclase
-
Legionella pneumophila
cytotoxin
cytlysis (cell death); lyses cells
-
Listeria monocytogenes
Listeriolysin
- lyses cells
- Membrane damage; similar in action to streptolysin O.
-
Pseudomonas aeruginosa
Exotoxin A
Type 3 cytotoxins
- cytolysis (cell death); kills cells
- Similar in action to diptheria toxin
- Adp ribosylation of elongation factor 2 results in the inhibition of protein synthesis.
- Modulate host cell physiology
- Inhibits actin cytoskeleton
-
Salmonella enterica serovars
type 3 cytotoxin
- Modulate host cell physiology
- Alters actin cytoskeleton.
-
Shigella dysenteriae
shiga toxin (enterotoxin)
- cytolysis (cell death); kills cells
- Inactivates 60s ribosome, thereby preventing protein synthesis.
-
Staphylococcus aureus
alpha
beta
gamma
toxic shock syndrome toxin
exfoliative toxin
- Hemolytic, leukocytic, paralysis of smooth muscle
- Pore-forming toxin
- cytolytis (cell death)
- sphingomyelinase
- cytolysis
- detergent-like action
- Food poisoning: emesis, diarrhea
- super antigen: activate host antibody and cytokine synthesis by an antigen independent action.
- Slouphing of skin, associated with scladed skin syndrome
- super antigen: protease
-
Streptococcus pneumonia
pneumolysin
- cytolysis
- Similar to streptolysin O- pore fore forming (membrane damage)
-
Streptococcus pyogenes
Streptolysin O
Erythrogenic toxin
- Cytolysis
- Pore-forming toxin
- Fevern neutropenia, rash associated with scarlet fever
-
Vibrio cholera
choleragen (enterotoxin)
- Diarrhea (secretory diarrhea)
- Adp ribosylation of adenylate cyclase results in its activation. This results in an increase in cAmp levels in a cell.
-
Yersinia enterocolitica
Heat-stable enterotoxin
Type three cytoxins
- Diarrhea
- Activate host guanylate cyclase
- Modulate host cell physiology
- Regulate cytoskeleton
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