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Name the 3 antisialogoges
Propantheline
Methantheline
Glycopyrrolate
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What are some side effects of antisialogoges?
Tachycardia, droosiness, decreased intestinal or bladder smooth muscle action
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Name 2 sialogoges? (parasympathomimetics)
Bethanecol
Cevimeline
Pilocarpine
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Contraindications of sialogoges (muscarinic agonists)?
Asthma and complete loss of salivary gland
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Unstimulated whole saliva flow range?
0.1-0.5 ml/min
parotid 25%, SM/SL 63%
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Stimulated saliva flow range?
1.1-3.0 ml/min
with acid 60% secreted by parotid comapred to only 25% unstimulated
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Cranial innervation from VII (7) to which glands?
Submand/Subling
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Cranial innervation IX (9) to which glands?
Parotid gland through otic ganglion
from Superior and inferior nuclei of brainstem
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What do mucins do?
provide viscosity, pellicle component, binding site for bacteria
large, hydrophilic, hydrated molecules
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What do lactoferrins do?
binds iron, inhibits bacterial growth
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What do lysozymes do?
antimicrobial, acts on cell wall
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What do histatins do?
histidine rich peptides
POWERFUL ANTIFUNGALS
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What do lactoperoxidases do?
forms hypothiocyanite ion, highly toxic to bacteria
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What does amylase do?
hydrolyzes starch, helps clear carbohydrate from, may be antimicrobial
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What do statherin's do?
tyrosine rich peptide
inhibits spontaneous CaPO4 precipitation, remineralizaiton of small lesions
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What to proline-rich proteins do ?
70% of protein make-up of saliva
bind tannins, control calculus
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What is the only negative inhibition for saliva production?
Fear-hypothalamus
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What ions are reabsorbed to make saliva hypotonic in collecting ducts?
Na+, Cl-
K+ and HCO3- are not reabsorbed
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What percent of acinar is storage of granules?
30% of cytoplasm
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What are the Calcium dependent channels, their location?
Potassium is basolateral
Chloride is apical
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How do we get potassium in during resting?
SPCC
Na/K ATPase (sodium 2 out and 3 K in)
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Recall the movement of ions in HCO3 dependent saliva secretion.
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Steps to ion transport when acinar cell is stimulated.
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