NSAID that also exhibits peripherally acting nonnarcotic analgesic activity by inhibiting prostaglandin synthesis.
Indications
Short-term management of moderate to severe pain.
Contraindications
Allergy to salicylates or other NSAIDs; patients with history of asthma; bleeding disorders, especially gastrointestinal (GI) related (peptic ulcer disease); renal failure.
Adverse reactions
Anaphylaxis due to hypersensitivity, nausea, GI bleeding, sedation, hypotension or hypertension, rash, headache, edema.
Drug Interactions
May increase bleeding time in patients taking anticoagulants.
How supplied
15 or 30 mg in 1-mL or 60 mg in 2-mL vials.
Dosage and Administration
Adult: 30-60 mg IM.
Pediatric: Not recommended
Duration of Action
Onset: 10 minutes.
Peak Effect: 1-2 hours.
Duration: 2-6 hours.
Special considerations
Pregnancy safety: Category C. Use with caution in elderly patient. May be given IV in lower dosage (15-30mg).