1. Glucagon
    Hyperglycemic agent, pancreatic hormone, insulin antagonist.
  2. Glucagon
    Mechanism of action
    Increases blood glucose level by stimulating glycogenesis (formation of glucagon). Unknown mechanism of stabilizing cardiac rhythm in beta-blocker overdose. Minimal positive inotropic and chronotropic response. Decrease gastrointestinal motility and secretions.
  3. Glucagon
    Altered level of consciousnesss when hypoglycemia is suspected. May be used as inotropic (affecting the contractility of cardiac muscle tissue) agent in beta-blocker overdose.
  4. Glucagon
    Hyperglycemia, hypersensitivity.
  5. Glucagon
    Adverse reactions
    Nausea, vomiting, tachycardia, hypertension.
  6. Glucagon
    Drug interactions
    Incompatible in solution with most other substances. No significant drug interactions with other emergency medications
  7. Glucagon
    How supplied
    1mg ampules (requires reconstitution with dilutent provided)
  8. Glucagon
    Dosage and administration
    • Adult: hypoglycemia: 0.5-1mg IM; may repeat in 7-10 min.
    • Calcium channel blocker or beta-blocker overdose: 3mg initially, followed by infusion at 3mg/hr as necessary.
    • Pediatric: Hypoglycemia: 0.5-1mg IM (for children <20kg).
    • Calcium channel blocker or beta blocker overdose: not recommended.
  9. Glucagon
    Duration of action
    • Onset: 1 minute
    • Peak effect: 30 minutes
    • Duration: variable (generally 9-17 minutes)
  10. Glucagon
    Special considerations
    Pregnancy safety: Category C. Ineffective if glycogen stores depleted. Should always be used in conjuction with 50% dextrose whenever possible. If Pt. does not respond to second dose glucagon, 50% dextrose must be administered.
Card Set
Paramedic Pharmacology