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- Fatty Change - SteatosisIntracellular
- 1) chronic- macrovesicular. trigylcerides, alcohol, reversible, nucleus off to side2) acute - microvesicular, fatty acids, drugs, irreversible, nucleus in middle
Oil red O would be best stain to use
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- Macrovesicular Fatty Change
- Intracellular
- chronic, nucleus pushed to periphery, triglycerides
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- Microvesicular Fatty Change
- Intracellular
- Acute, multiple small droplets around central nuclei, fatty acids
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- Glycogen Storage Disease
- Intracellular
- white space around nucleus (perinuclear)
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- Mallory Bodies
- Intracellular
- Heat Shock Proteins + Intermediate Filaments
Described as Hyalin, indicates cell damage
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- Hemosiderosis
- intraceulluar pigment accumulation - heme derived
- macrophages containing hemosiderin = "Heart Failure Cells"
- Stain golden brown
- localized
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- Hemosiderosis
- intraceulluar pigment accumulation - heme derived
- macrophages containing hemosiderin = "Heart Failure Cells"
- Stain golden brown
- systemic- from blood transfusions
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 - intraceulluar pigment accumulation - heme derived
- regeneration nodule, primary, secondary
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Hemosiderin, prussian blue, systemic
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- bile accumulation in canaliculi
- heme-derived intracellular
- grossly, tissue would look yellow
- jaundice
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- Copper Accumulation
- Non-heme derived pigment accumulation
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- Melanin Accumulation
- Intracellular, non-heme derived
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- Amyloidosis
- Interstitial Accumulation
- Misfolded amyloids (amyloids are normally present)- beta pleated sheets. AA, AL
- can use congo red to light it up
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- Dystrophic Calcification
- Interstitial Accumulation
- High serum, normal tissue
- localized, calcium stains dark purple
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- Metastatic Calcification
- Interstitial Accumulation
- Normal Serum, Abnormal Tissue
- all over, calcium stains dark purple
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