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Hydropic Change
 - Remember: Ischemia --> Hydropic Change
- No O2--> no ATP --> Na + Water into cell
- pH lowers, dilation of ER, ribosomes detach, cristae misalign. Blebbing
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Hydropic Change
Remember: Ischemia --> Hydropic ChangeNo O2--> no ATP --> Na + Water into cellpH lowers, dilation of ER, ribosomes detach, cristae misalign. Blebbing
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- Areas of infarct
- Note the "wedge" shapes
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- Necrosis Due to Infarct
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- Coagulative Necrosis
- Caused by ischemia
- Note the preservation of tissue architecture but the lack of nuclei
Ex: myocardial infarction
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- Coagulative Necrosis
- Caused by ischemia
- Note the preservation of tissue architecture but the lack of nuclei
- Ex: myocardial infarction
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- Liquefactive Necrosis
- Occurs in:
- 1-brain injury due to ischemia (stroke)
- 2- abcess formation
You see no real structure or membranes usually. Just inflammatory cells
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- Liquefactive Necrosis
- Occurs in:
- 1-brain injury due to ischemia (stroke)
- 2- abcess formation
You see no real structure or membranes usually. Just inflammatory cells
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- Occurs in:
- 1-brain injury due to ischemia (stroke)
- 2- abcess formation
- You see no real structure or membranes usually. Just inflammatory cells
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- Liquefactive Necrosis: Abcess
- Difference from granuloma: note that abcess stains with eosin because of all the inflammatory cells
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Caseous Necrosis
You can only use this term to describe grossly
Microscopically: granuloma
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Fat Necrosis
- 1) Enzymatic- most common cause is alcohol. inflammation causes leakage of digestive enzymes, which attack local fat cells. "ghost cells"
- 2) Non-enzymatic- due to trauma
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- Fat Necrosis
- 1) Enzymatic- most common cause is alcohol. inflammation causes leakage of digestive enzymes, which attack local fat cells. "ghost cells"
- 2) Non-enzymatic- due to trauma
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- Fibrinoid Necrosis
- microscopic change in arterioles, caused by malignant hypertension or autoimmune disease
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Apoptosis
Intense Eosinophilia and loss of nucleus
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