Pathology Images - Effect of Injury on Tissue 1

Hydropic Change

• Remember: Ischemia --> Hydropic Change
• No O2--> no ATP --> Na + Water into cell
• pH lowers, dilation of ER, ribosomes detach, cristae misalign. Blebbing

Hydropic Change

Remember: Ischemia --> Hydropic ChangeNo O2--> no ATP --> Na + Water into cellpH lowers, dilation of ER, ribosomes detach, cristae misalign. Blebbing

• Areas of infarct
• Note the "wedge" shapes

• Necrosis Due to Infarct

• Coagulative Necrosis
• Caused by ischemia
• Note the preservation of tissue architecture but the lack of nuclei

Ex: myocardial infarction

• Coagulative Necrosis
• Caused by ischemia
• Note the preservation of tissue architecture but the lack of nuclei
• Ex: myocardial infarction

• Liquefactive Necrosis
• Occurs in:
• 1-brain injury due to ischemia (stroke)
• 2- abcess formation

You see no real structure or membranes usually. Just inflammatory cells

• Liquefactive Necrosis
• Occurs in:
• 1-brain injury due to ischemia (stroke)
• 2- abcess formation

You see no real structure or membranes usually. Just inflammatory cells

• Occurs in:
• 1-brain injury due to ischemia (stroke)
• 2- abcess formation
• You see no real structure or membranes usually. Just inflammatory cells

• Liquefactive Necrosis: Abcess
• Difference from granuloma: note that abcess stains with eosin because of all the inflammatory cells

Caseous Necrosis

You can only use this term to describe grossly

Microscopically: granuloma

Fat Necrosis

• 1) Enzymatic- most common cause is alcohol. inflammation causes leakage of digestive enzymes, which attack local fat cells. "ghost cells"
• 2) Non-enzymatic- due to trauma

• Fat Necrosis
• 1) Enzymatic- most common cause is alcohol. inflammation causes leakage of digestive enzymes, which attack local fat cells. "ghost cells"
• 2) Non-enzymatic- due to trauma

• Fibrinoid Necrosis
• microscopic change in arterioles, caused by malignant hypertension or autoimmune disease

Apoptosis

Intense Eosinophilia and loss of nucleus