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Heart Failure and Digoxin.txt

  1. Digoxin is used with _______ heart failure, not _______ heart failure
    • systolic
    • dialstolic- do not give in diastolic heart failure!!
  2. First line treatment for Heart Failure???
    2nd
    3rd
    4th
    • 1st-Loop diuretics-for fluid retention.
    • 2nd- ACEI and ARB's
    • 3rd- BB
    • 4th-Digoxin
  3. True or False:
    Digoxin decreases mortality rate?
    • False
    • Dig does not decrease mortality rate.

    mostly treats s/s
  4. Dig is only given to patients with _______ and _______?
    heart failure and afib/flutter (antiarrhythmic properties)
  5. Do not use dig with patients with......
    • SSS
    • Heart block  (unless they have a pacer)
    • if taking BB or amiodarone
  6. Dig class is??
    cardiac glycoside
  7. Dig MOA???
    • Inhibits sodium potassium adenosine triphosphate activity, which enhances calcium entry into the cell. 
    • Calcium increases contractility and velocity of contraction= better output b/c heart is pumping better.

    • GOAL---decrease workload of heart!
    • BOTTOM LINE= REDUCES WORK LOAD OF THE HEART.
  8. Dig dosage

    Therapeutic dosage
    0.25 mg every day, if there is no renal dysfunction. If renal dysfunction 0.125mg daily

    Levels 0.9-1.2 mg/ml are therapeutic
  9. Symptoms of Dig Toxicity??
    • anorexia
    • n/v
    • halo around objects
  10. What type of dietary recommendations with Digoxin?
    Do not use salt substitutes, they are full of potassium and can lead to hyperkalemia.
  11. What do you use in diastolic heart failure
    NOT DIG!!!

    BB ARE USED
  12. What drugs can worsen systolic heart failure?
    CCB!! (may be useful in diastolic HF)

    CCB can worsen SHF especially verapamil and Cardizem!!!  they have negative inotropic effect on the heart.
  13. What can verapamil and Cardizem do in SHF??
    What effect do they have?
    • They can worsen SHF
    • Have a negative inotropic effect on heart.
  14. Treatment principle of Dig
    Start low and go slow!!!
  15. If you switch patient form digoxin to generic lanoxin what are you going to have to start doing again?
    Going to have to start the monitoring process all over again.
  16. Once dig is started it is a ______ drug?
    • life time drug
    • You can never go off of it
  17. 1/2 life of Dig
    How long to reach steady state
    • 36 hours
    • takes about 5 days to reach steady state.
  18. Creatinine clearance of 10-50 ml/min
    How much would you decrease the dose?
    • 25-75%
    • REMEBER TO JUST GIVE ABOUT HALF THE DOSE.
  19. When to draw dig levels when checking for toxicity?
    6-8 hours after last does and ideally just before the next dose.  If you draw dig levels too soon they will be wrong.
  20. Dig toxicity symptoms
    Visual disturbances, and sensitivity to light,  yellow halo and blurry vision

    • anorexia
    • headache
    • fatigue
    • malaise
    • disorientation
    • delirium
    • confusion
    • seizures
  21. 18% of dig toxic patients die from_____?
    arrhythmias
  22. Dig should be stopped with plans to restart in 2-3 days if any of the following occur?
    • elevated dig level
    • substantial reduction in renal function
    • symptoms of toxicity
    • significant conduction abnormalities
    • increase in ventricular arrhythmias
  23. Drug interactions with Dig
    BB- can result in complete heart block

    Erythromycin, clarithromycin, tetracycline may increase absorption of dig and result in toxicity

    Thyroid replacement drugs increase the dose of dig needed. (thyroid replacement increases metabolism, that is why it is needed)
Author
Corissa.Stovall
ID
240864
Card Set
Heart Failure and Digoxin.txt
Description
Pharm Test 2
Updated

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