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Acute and chronic rhinitis
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classes used to treat allergic rhinitis
1st generation antihistamines
2nd generation antihistamines
inhibitors of mast cell degranulation
corticosteroids
mast cell degranulation inhibitors are derivatives of what
benzopyrone
antazoline
vasocon A
is vascon acidic or basic
basic
what ring structure is antazoline characterized by
imidazole ring
what type of metabolism can be expected from antazoline in the body
aromatic hydroxylation and conjugation
what is the chemical structure name for benadryl
ethanolamine
clemastine
tavist
how many chiral centers and diasteromers does clemastine have
2 chiral centers and 4 diasteromers
chlorpheniramine
chlortrimeton
name some characteristics of chlorpheniramine
longer half life than most 1st gen antihistamines
fewer central effects than ethanolamine and ethylenediamenes
what is the decreased sedation of the 2nd generation antihistamines due to
improved H1 selectivity and amphoteric structures
which class is loratadine related to
TCAs
how is loratadine metabolized
oxidation of ethyl carbamate to des-loratadine (not a direct hydrolysis)
zyrtec is the metabolite of what
hydroxyzine
which classes is cetirizine related to
ethanolamine
ethylenediamine
fexofenadine
allegra
cetirizine has what functional group
piperazine
allegra has what functional group
piperidine
fexofenadine is the metabolite of what
carboxylic acid metabolite of terfenadine
mometasone furoate
nasonex
ciclesonide
omnaris
how are corticosteroid anti-inflm compounds excreted from the body
unchanged (or hydrolyzed) in the feces
atrovent
ipratropium bromide
atrovent is similar to what agent
atropine
what is atrovent classified as
an amino alcohol ester
how is ipratropium metabolized
by hydrolysis then excreted
cromolyn sodium
nasalcrom
what is cromolyn classified as
bischromone (benzopyrone)
how long will it take for the max response of cromolyn
2 - 4 weeks
what is the drug of choice for rhinorrhea in pregnancy
cromolyn
how is cromolyn excreted
unchanged in bile and urine
Author
Anonymous
ID
240245
Card Set
Acute and chronic rhinitis
Description
PT IV Exam II
Updated
2013-10-12T23:32:06Z
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