-
Most bronchogenic carcinomas present between the ages ______, and few are less than ____ years old
-
what other factors can be potential carcinogens
- Ionizing radiation
- asbestos
- heavy metals
- industrial carcinogens
-
What are the four major cell types of bronchogenic carcinomas
- Squamous cell carcinoma
- adenocarcinoma
- small cell carcinoma
- large cell carcinoma
-
What are the most common carcinomas accounting for about 30 to 35% of primary tumors each
- Squamous cell
- adenocarcinoma
-
What are the carcinomas accounting for 20 to 25% and 15% respectively
Small cell and large cell
-
Which type of carcinoma tends to originate in the central bronchi as intraluminal growth
Squamous cell carcinoma
-
Which carcinoma can be detected by sputum cytology
Squamous cell carcinoma
-
Where does squamous cell carcinoma tend to metastasize
Regional lymph nodes
-
This type of carcinoma also occurs centrally and tends to narrow bronchi by the extrinsic compression
Small cell carcinoma
-
Which type of carcinomas usually appear in the periphery and metastasize to distant organs
Adenocarcinoma and large cell
-
Where does adenocarcinoma and large cell carcinoma metastasize to
- Liver
- stomach
- spleen
- pancreas
-
What are the non specific complaints for carcinomas
- Weight loss
- cough
- poor appetite
- dyspnea
- hoarseness
- hemoptysis
-
This is a tumor of the superior sulcus at the extreme apex of the lungs, it is characterized by severe unremitting pain in the lower part of the shoulder and inner aspect of the arm
Pancoast tumor
-
Which tumor can progress to horner's syndrome (miosis, ptosis, enophthalmos, and loss of sweating on the affected side)
Pancoast tumor
-
Which plexus does the Pancoast tumor affect
brachial plexus
-
What are some examples of paraneoplastic syndromes
- Cushings syndrome
- syndrome of inappropriate secretion of anti diuretic hormone
- hypercalcemia
- gynecomastia
-
Which carcinoma can produce SIADH
Small cell carcinoma
-
If this is a obstructed by a tumor, it can cause progressive obstruction of venous drainage of the head, neck, and upper extremities
Superior vena cava
-
Under tumor complications, what results in hoarseness
Recurrent laryngeal nerve palsy from tumor destruction of recurrent laryngeal nerve creating laryngeal nerve palsy
-
What labs need to be ordered for all suspected lung cancer patients
- CBC
- LFT
- electrolytes
- calcium
-
What is the definitive diagnosis for the more centrally located carcinomas
Sputum cytology
-
What is essential in determining staging, treatment, and prognosis of carcinomas
Knowing the specific cancer type
-
If you see a suspicious legion on and xray what is your next choice of scan
CT
-
If you want to see if the cancer has metastasized, what it is your choice of study
MRI
-
What is the treatment of choice for small cell carcinoma
Chemotherapy and radiation
-
What are the major factors for prognosis of carcinomas
- Cell type
- age
- General Health
-
This is a single round or oval sharply circumscribed pulmonary lesion, up to three centimeters, surrounded by normal lung tissue
Solitary pulmonary nodule
-
What disrupts cell function and prevents tissue from taking up oxygen
Cyanide
-
What are the symptoms of cyanide poisoning
- Headache
- dizziness
- syncope
- seizures
- death
-
This is a precursor to vitamin B12, binds to cyanide and neutralizes it, is eliminated harmlessly from the body through urination, and is given intravenously and acts immediately
hydroxocobalamin
-
What are the side effects of hydroxocobalamin
Temporary discoloration of the skin and urine
-
This occurs from inhalation of hot gases injuring mucosal surfaces, complications become evident around 18 to 24 hours, complications include impaired ability to clear oral secretions and airway obstructions, producing inspiratory stridor
Thermal injury
-
This results from the toxic gases produced by combustion, it can result in bronchorrhea and bronchospasm's, early with possible labored breathing and cyanosis, ARDS may follow in 1 to 2 days
Chemical injury
-
with chemical injury, this can occur causing obstruction, atelectasis, and increasing hypoxemia, often pneumonia follows 5 to 7 days after exposure
Bronchial sloughing
-
Why does the treatment of smoke inhalation include
- Supplemental 02
- bronchodilators
- suction of secretions
- endotracheal intubation
- chest physical therapy
- humidified oxygen
-
For patients that survive smoke inhalation follow-up is needed to monitor for what
bronchiolitis obliterans
-
This is caused by ingestion of petroleum distillates, lung injury mainly from vomiting and secondary aspiration, therapy as supportive, protect lungs from repeated aspiration with cuffed endotracheal tube if necessary
hydrocarbon pneumonitis
-
This is chronic fibrotic lung disease is caused by inhalation of coal dust and various inert, inorganic, or silicate dusts
pneumoconiosis
-
This is caused from extensive or prolonged inhalation of free silica particles forming small rounded opacities through out the lung
Silicosis
-
On a chest xray, what strongly suggests silicosis
Eggshell calcification
-
Asbestosis is a nodular interstitial fibrosis occurring in which occupations
Asbestos workers and miners
-
This is an asthma like disorder in textile workers caused by inhalation of cotton dust, symptoms include chest tightness, cough, dyspnea and usually is worse on Mondays or the first day back to where, and subsides later in the week
byssinosis
-
This occurs in extremely obese individuals characterized by hypercapnia, hypoxemia, and elevated hematocrit
pickwickian syndrome
-
What it is the treatment for pickwickian syndrome
Weight loss and medroxyprogesterone acetate (Provera)
-
How is hypercapnia and hypoxemia corrected in pickwickian syndrome
Have patient hyperventilate and the PCO2 and PO2 will return to normal
-
What is the number one arrhythmia associated with pickwickian syndrome
PVCs
-
what are the essentials to diagnosing a PE
- abrupt onset of dyspnea
- chest pain
- apprehension
- hemoptysis
- syncope
-
what is the scan of choice for detection of a PE
spiral CT with contrast
-
where can PEs arise from
- thrombi in venous circulation
- right side of heart (pt has an ASD and the clot can go to the lungs)
-
70% of PEs originate as clots in deep veins of ____, mostly in the _____
-
what is virchows triad
- venous stasis (long airplane rides or post-op)
- venous endothelial injury
- hypercoagulopathy (OCP, CA)
-
what is the most common cause of PEs in the Caucasian population
factor V leiden
-
what causes factor V leiden thrombopenia
mutations in the F5 gene
-
a thrombus in the pulmonary artery has hemodynamic effects that affect what
causes an increase in pulmonary vascular resistance and at the extremes causes pulmonary HTN and right ventricle failure
-
what are the pulmonary effects of a PE
- pt will get reflex bronchoconstriction in the embolized area
- they will also get increased dead space and loss of alveolar surfactant
-
what are the signs that a pt will present with for a PE
- tachycardia
- tachypnea
- crackles
- accentuation of pulmonary component of second heart sound
-
what are the symptoms of a PE
- CP (often pleuritic)
- dyspnea
- apprehension
- cough
- hemoptysis
- diaphoresis
-
an ABG will usually note what for a PE
respiratory alkalosis secondary to hyperventilation (usually PaO2 under 80mmHg)
-
what is rarely seen on a CXR but is very suggestive of a PE
Hampton's hump (wedge shaped density pointing towards hilum)
-
if you have an indeterminant study for a PE after doing a helical CT-PA what should be done next to r/o a PE
LE U/S or PA (pulmonary angiogram)
-
this study is reserved for pt's with a suspected emboli but other studies are inconclusive, it is expensive and invasive with potential for complications and is less than the "gold standard"
pulmonary angiogram
-
with any IV radio contrast-media, what do you need to worry about
- acute renal failure
- allergic reactions
-
this test measures the plasma level of a degradation product of a cross linked fibrin, is measured by ELISA, and takes about an hour to perform
D-Dimer
-
what measurement difference between calves is highly indicative of a DVT
if one calf is greater than 2cm compared to the contralateral calf
-
if a DVT is suspected and there are no CI, what should be started
IV heparin
-
this sign is said to be present when passive dorsiflexion of the ankle by the examiner elicits sharp pain in the calf
homans sign
-
what is the diagnostic study if a DVT is suspected
U/S
-
what should be started on pts at risk to prevent DVTs before surgery or on hospital admission
low dose heparin (5000 units) SQ q 8-12 hours
-
extremely high risk pt's or surgeries may require what type of prevention
prophylactic inferior vena cava filter
-
what is the timeframe to reach full therapeutic effect of coumadin
5 days
-
this anti-coag works by activating AT-III to slow or prevent the progression of DVT and to reduce the size and frequency of PE
heparin
-
what is the reversal of heparin
protamine sulfate
-
what are the medications used for lysis of pulmonary thromboembolia
- streptokinase
- urokinase
- recombinant tissue plasminogen activator (TPA)
-
what treatment is indicated when recurrent PEs are life threatening and major CIs for anticoag or failure or complications of anticoags or thrombolytic therapy are present
surgical interruption of inferior vena cava
-
pain due to acute pleural inflammation is known as what
pleuritis
-
explain pleuritis
inflammation of the pleura that causes loos of lubricant between them, inspiration causes the friction rub when the pleura rub together
-
how is pleuritis treated
analgesics and anti-inflammatory drugs
-
what is another cause for pain that is pleuritic but is not pleuritis
rib fracture
-
in a rib fracture or pleuritis, lack of proper ventilation can lead to this
atelectasis
-
this may be asymptomatic, may be pleuritic, may cause dyspnea, will notice decreased tactile fremitus on physical exam along with dullness to percussion, distant breath sounds and egophony if large
pleural effusion
-
how much fluid must be present in the lateral decubitus to be considered effusion
> 250ml
-
what should be done to yield fluid for a diagnosis of the etiology of effusion
thoracentesis
-
what accounts for most transudates and is the most common cause of pleural effusion
CHF
-
what are the most common causes of exudative effusion
bacterial pneumonia and CA
-
TG readings of what can detect a chylothorax
> 110mg/dL
-
what labs are used to detect an esophageal perforation
amylase >200
-
one treatment option for palliative pain control in a pleural effusion is what
pleurodesis (they obliterate the pleura with chemicals so it can no longer rub against each other)
-
what is the treatment for effusion secondary to pneumonia
preventing the exudative fluid from turning into frank pus
-
what is required for frank pus
tube thoracostomy
-
primary spontaneous pneumothorax usually affects what types of people
tall thin men between 20 and 40
-
why do spontaneous pneumos occur in tall thin males
because of the narrow apices (surface area) for the lungs to attach. they have a congenital bleb and it bursts which develops the spontaneous pneumo
-
what are some causes for secondary pneumos
- COPD
- asthma
- cystic fibrosis
- TB
- pneumocystis pneumonia
-
this type of pneumothorax is associated with menstruation
catamenial pneumothorax
-
what are some clinical finds for a pneumo
sudden onset of one sided CP and dyspnea, often begins at rest or sleep
-
what are some clinical findings for a pneumo
- diminished breath sounds
- decreased tactile fremitus
- hyperresonance on one side
-
if there is severe tachycardia, HoTN, and a mediastinal or tracheal shift what needs to be suspected
tension pneumo
-
a pneumo is usually revealed on a CXR by noting what
a visceral pleural line
-
most congenital bleb pneumos occur where
apices
-
a tension pneumo will result in what
acute respiratory failure within 5 minutes
-
what can be associated with a rupture of the esophagus or bronchus
pneumomediastinum
-
what is the treatment for a pneumo is <15%
conservative with bed rest, symptomatic care and serial CXRs
-
what is the treatment for a pneumo that is > 15%
a chest tube is usually placed under water sealed drainage and suction is applied until lung expands
-
this is a primary tumor arising from the surface lining of the pleura or peritoneum, symptoms include insidious onset of SOB, non pleuritic CP, weight loss
mesothelioma
-
what will a CXR show with mesothelioma
nodular, irregular, unilateral pleural thickening, and sometimes unilateral effusion
-
what are common features of interstitial and mycotic lung diseases
inflammation and fibrosis of the interalveolar septum (alveolitis)
-
these diseases will have a decrease in DLCO and ventilator function, usually present with exertional dyspnea and dry cough of insidious onset, and chest exam is notable for fine inspiratory crackles at bases
interstitial diseases
-
this disease has a CXR that notes ground-glass, nodular, reticular or reticulonodular infiltrates that may progress to honeycomb lung
interstitial disease
-
what is very good for diagnosis of interstitial diseases
high resolution CT
-
what is used for pathological diagnosis of interstitial diseases
lung biopsy
-
what is the most common diagnosis presenting with interstitial lung disease
cryptogenic fibrosing alveolitis (idiopathic pulmonary fibrosis)
-
what is the treatment for cryptogenic fibrosing alveolitis
- supportive care
- supplemental O2
- corticosteroids
-
what is the prognosis of cryptogenic fibrosing alveolitis
poor with a 5-year survival rate of about 50%
-
pts with cryptogenic fibrosing alveolitis have an increased risk of what
lung cancer
-
this is a systemic disease of unknown cause with granulomatous inflammation of the lung in 90% of pts, pt may have malaise, fever, and dyspnea of insidious onset
sarcoidosis
-
physical findings of this disease include skin rashes, erythema nodosum, parotid gland enlargement, hepatosplenomegaly, lymphadenopathy
sarcoidosis
-
the first signs of sarcoidosis is noted on a routine CXR how
bilateral hilar and paratracheal lymphadenopathy
-
what is the treatment for sarcoidosis
oral corticosteroids is indicated for symptomatic pulmonary lesions and constitutional symptoms, hypercalcemia, iritis, arthritis, CNS involvement, granulomatous hepatitis, cutaneous lesions
-
if a patient has asymptomatic sarcoidosis, how are they treated
educate and f/u
-
this is an idiopathic disease hitting a combination of glomerulonephritis, necrotizing granulomatous vasculitis of upper and lower respiratory tracts, and varying degrees of small vessel vasculitis , it usually affects young and middle aged adults
Wegener's granulomatosis
-
this is an idiopathic multisystem vasculitis of small and medium-sized arteries that occurs in pts with asthma
churg-strauss syndrome
-
how is pulmonary angiitis and granulomatosis treated
corticosteroids but can have a devastating irreversible lung involvement
-
this causes an idiopathic recurrent alveolar hemorrhage and rapidly progressive glomerulonephritis, occurs mainly is men who are in their 30's and 40's, and hemoptysis is the presenting symptom
goodpasture's syndrome
-
who is goodpastures syndrome diagnosed
it is made on a characteristic linear IgG deposits in the glomeruli and presence of anti-glomerular basement membrane antibody in serum
-
what is the current treatment of goodpasture syndrome
immunosuppressive drugs and plasmapheresis
-
this disease is linked to bird droppings and bat exposure, is very common along river valleys
histoplasmosis
-
what is the treatment for histoplasmosis
antifungals (amphotericin B)
-
this is endemic in the soil in many arid regions of the southwestern USA, mexico, and south and central America, is a very common opportunistic infection in HIV-infected pts and symptoms include flu-like with malaise, fever, backache, and cough
coccidioidomycosis
-
this disease occurs most often in men of the south central and Midwestern USA and Canada, may often see skin lesions with verrucous cutaneous lesions with abrupt down-sloping border, and can also affect the bone and urogenital system
blastomycosis
-
this can colonize the tracheobronchial tree and is usually asymptomatic unless there is marked immunodeficiency
aspergillosis
-
what unique condition can aspergillosis cause that leads to wheezing and transient infiltrates
allergic bronchopulmonary aspergillosis
-
when should allergic bronchopulmonary aspergillosis be considered in a pt
when a pt with a hx of asthma develops worsening symptoms, with fleeting infiltrates accomplanied with eosinophilia, high level of IgE, and brown-flecked sputum
-
how is allergic brochopulmonary aspergillosis treated
acute exacerbation: oral prednisone, bronchodilators
-
what is the rough definition of acute respiratory failure by ABGs in a non-COPD pt
PaO2 <60 (after attempted to increase the PaO2) and a PaCO2 >50
-
what are some chief signs of hypoxemia
- cyanosis
- restlessness
- confusion
- anxiety
- delirium
- tachypnea
- tachycardia
- HTN
- cardiac arrhythmias
- tremor
-
what are some cardinal symptoms of hypercapnia
dyspnea and H/A
-
what are some chief sign of hypercapnia
- peripheral and conjunctival hyperemia
- HTN
- tachycardia
- tachypnea
- impaired consciousness
- papilledema
- asterixis (flapping tremor with hand extended.. like a bird flapping its wings)
-
for non ventilator support, what is the goal in acute hypoxemic respiratory failure
to provide adequate oxygenation of vital organs
-
what is the only mask that will give you an exact FiO2 % up to 40-50% of O2
venture mask
-
which mask do you never run <5L/min
simple mask
-
which mask has the highest FiO2 on a mask
NRB
-
how high should a nasal cannula run
<6L/min (never above 6L/min)
-
what determines how long a cylinder will last
conversion factor
-
what is indicated for hypoxemia not quickly reversible, for upper airway obstruction, impaired airway protection, poor handling of secretions, and facilitation of mechanical ventilation
tracheal intubation
-
how far in an ET tube inserted
below the vocal cords 1-2 cm above the carina (T4)
-
this is great for urgent airway management
orotracheal intubation (but nasotracheal is more comfortable for long term intubation)
-
the tip of the tube once intubated should be at the level of what
aortic arch
-
what are some indications for mechanical ventilation
- apnea (#1 reason)
- acute hypercapnia not quickly reversible
- severe hypoxemia
- progressive pt fatigue despite appropriate care
-
this can occur in pts whose lungs are over distended by too great a volume or pressure
barotrauma
-
what are some signs of barotrauma
- subcutaneous emphysema
- subpleural air cysts
-
what is a common ventilator complication
acute respiratory alkalosis from overventilation
-
what are labs are ordered to check the patients general health while ventilated
- hematocrit
- electrolytes
- kidney functions
-
this is a special type of respiratory failure, it occurs after a systemic or pulmonary insult, is characterized by respiratory distress, bilateral infiltrates, hypoxemia, noncompliant lungs, and normal pulmonary capillary wedge pressure
ARDS
-
what are the common risk factors for ARDS
- sepsis (very common)
- aspiration of gastric content
- shock
- infx
- lung contusion
- non thoracic trauma
- toxic inhalation
- near drowning
- multiple blood transfusions
-
what are the clinical findings of ARDS
- rapid onset of profound dyspnea that usually occurs 12-48 hours after the initial event
- labored breathing
- tachypnea
- intercostal retractions
- crackles
- marked hypoxemia refractory to supplemental O2
-
what is the treatment for ARDS
- general supportive care
- support of cardiac function with inotropic drugs (dopamine)
- closely monitor I/O's
-
what is the major cause of death in ARDS
multi-organ failure
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