-
what is the MOA of metronidazole
- inhibits DNA synthesis
- causes DNA breakage
- inhibit respiration in anaerobic organisms
-
what is the MOA of Acyclovir
- inhibits viral DNA chain elongation
- inactivation of viral DNA polymerase
-
what is the MOA of foscovir
binds to pyrophosphate sites on viral DNA polymerase and inhibits DNA synthesis
-
what is the causative agent of genital warts
HPV
-
what is the causative agent of genital herpes
-
what is the causative agent of trichomoniasis
trichomonas vaginalis
-
what is the causative agent of chancroid
haemophilus ducreyi
-
what is the causative agent of lymphogranuloma venereum
chlamydia trachomatis
-
what is the causative agent of granuloma inguinale
klebsiella granulomatis
-
what is the distinguishing features of bacterial vaginosis
- clue cells (squamous cells loaded with rods)
- whiff test (10% KOH + vag secretion)
- light and homogenous secretion
- dysuria, pruritus, tenderness, dyspareunia
-
what is the distinguishing features of trichomoniasis
- purulent, greenish-yellow vag disharge
- strawberry-like lesions
-
what are the AE of Foscarnet
- nephrotox
- anemia
- electrolyte imbalance
- -decrease in Ca2+, K+, Mg2+, PO4-
- -can have increase or decrease in PO4-
-
agents used to treat genital warts
- podophyllin
- trichloracetic acid
- podofilox
- aldara
- cryotherapy (liquid nitrogen)
- atovirsen
- laser surgery
- accusite
- intralesional (INF-alpha)-2b or 2a
- Gardasil
- Cervarix
-
list agents used to treat intestinal amebiases
- erythromycin (PO)
- aminoglycosides
- tetracyclines
-
can agents used in intestinal amebiasis be used to treat extra-intestinal amebiasis
NO
-
agents used to treat extra-intestinal amebiasis
- flagyl
- tinidazole
- emetine
- chloroquine
- *can also be used for intestinal
-
agents used to treat giardiasis
- flagyl
- tinidazole
- quinicrine
- furoxone
-
what is the route of administration of acyclovir
PO, topical, IV
-
how does food effect the oral absorption of acyclovir
it does not effect it
-
what is the f factor for acyclovir
15-30%
-
what is the t1/2 of acyclovir
2.5 hours
-
what is the PPB of acyclovir
9-33% (very low)
-
how is acyclovir excreted
- renally (60-92%)
- feces
- pulmonary system as CO2 (expiration)
-
-
-
clindamycin
cleocin (trichomonas)
-
viramidine
taribavarin (Hep C)
-
-
Baraclude
entecavir (hep b)
-
famvir
famciclovir (hep b and herpes)
-
emtricitabine
emtriva (hep b)
-
telbuvidine
tyzeka (hep b)
-
gardisil
HPV vaccine (warts)
-
Cevarix
HPV vaccine (warts)
-
trichloracetic acid
tri-chlor (warts)
-
podofilox
(condylox) warts
-
-
valacyclovir
Valtrex (herpes)
-
ganciclovir
cytovene (herpes)
-
valganciclovir
valcyte (herpes)
-
pensiclovir
Denavir (herpes)
-
rebetol
ribavirin (herpes, hep c)
-
phosphonoformic acid
foscarnet
-
-
foscarnet
phosphonoformic acid, foscovir
-
-
-
-
-
-
-
-
tri-chlor
trichloracetic acid
-
-
-
-
-
-
-
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