The flashcards below were created by user
Aleksbaron
on FreezingBlue Flashcards.
-
What is the initial periapical immune response comprised of? Chronic?
Innate immunity with phagocytic leukocytes and cytokines
Adaptive immunity takes over when chronic
-
Where are APC dendritic cells found in pulp?
Odontoblastic layer
-
Where are the macrophage like cells found in pulp?
Centrally in pulp
-
Describe the presence of adaptive immunity components in the pulp?
Small number of T cells (BVs), B cells rare, plasma cell progeny are absent.
-
Earliest pulp response to bacteria includes infiltration of?
PMNs, neutrophils, monocytes, NK cells
mechanism is incapable of clearing the infection
-
Describe the second line defense of the immune response in the pulp?
purpose of immune response is to localize the infection within the confines of the root canal system and prevent it's travel to the whole body
-
How can teeth be vital and cause pain with periapical radiolucencies?
tissue destruction is indirect by soluble host-derived mediators
osteoclastogenesis is dependent on innate immune response which is first to occur
-
What cells comprise the mixed infiltrate of the immune response?
- 1. T
- 2. B
- 3. PMNs
- 4. Macro
- 5. DC
- 6. Plasma
- 7. NK
- 8. Eosinophils
- 9. Mast
-
Which cells are most numerous in immune response?
Lymphocytes or macrophages
-
What are the three types of DCs?
Myeloid
PLasmacytoid
Monocyte-derived
-
Describe levels of immunoglobulins with caries present?
IgG1>IgA1, IgM, IgA2
-
Describe levels of plasma cells during chronic lesions?
IgG (.7) IgA (.14) IgE (.1) IgM (.04)
-
What are the potentially destructive products of PMNs?
Elastase, cathepsin G, leukotriene B4
-
Name some diseases that have PMNs defects
Chronic granulomatous disease
Cyclic neutropenia
Papillon-Lefevre syndrome
Chediak Higashi syndrome
Leukocyte adhesion deficencies (LADs)
-
Describe LADs.
LAD-1: genetic defect of integrins affects transmigration
LAD-2: defect in sialyl Lewis X ligand affects rolling adhesion
-
What two drugs cause neutropenia?
Cyclophosphamide and methotrexate
-
What cytokine stimulates the anti-bacterial properties of mature neutrophils?
G-CSF
-
This biologic modifier is derived from yeast?
PGG Glucan
reduced bone destruction by 40% in periapical lesion
-
How do PMNs play a role in neurogenic inflammtion?
secrete Subst. P
-
Name some adaptive immunity diseases.
SCID (severe combined immunodef)
DiGeorge Syndrome (thymic aplasia)
hypogammaglobulinemias
selective IgA and IgG deficencies
-
SCID is defects in both?
Humoral and Cellular immunity
-
Which cytokine "primes" PMNs for elevated oxidative burst?
IL-8,
also IL-1 and TNF (prime for better phagocytosis)
-
Which two chemokines synergize to increase inflammatory responses?
IL-6 and PGE2: increase inflammatory response (IL-6 prim anti-inf)
IL-1 and PGE2: bone resorption
-
What chemokines comprise the osteoclast-actviating factor (OAF)?
IL-1alpha
IL-1beta (most activity) (stimulate RANKL)
TNF-alpha
TNF-beta
-
Only 10-15% of resorptive action is due to what chemokine?
PGE2
60% is by IL-1
-
IL-1beta is _____ times more potent than TNF in bone resorption.
500
-
What are autacoids?
Termed resolvins, produced by acetylated COX-2 from omega-3 fatty acids
-
Name anti-inf cytokines.
IL-4,5,6,10,13
|
|