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Tissue
A collection of specialized cells and cell products that preform a relatively limited number of functions
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Histology
the study of tissues
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4 main tissues
Epithelial, connective, muscle, Neural
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Epithelial systems
Epithelia and glands
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Epithelial functions
1.Provide physical protection 2. control permeability 3.provide sensation 4.produce specialized secretions
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Epithelial characteristics
1) Cellularity 2) Polarity 3) Attachment 4) A vascularity 5) regeneration
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Cell integrity is maintained in 3 ways
1)Intercellular connections 2) Attachment to basal lamia 3) Epithelial maintenance
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3 Broad classifications of Epithelial
1) Squamous ( mouth/throat) 2) Cuboidal (Kidney and sweat) 3) Columnar (stomach and anus)
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2 kinds of Glandular Epithelia
1) Endocrine (hormones) 2. Exocrine (epithelial surface)
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3 Modes of Secretion
Merocrine, Apocrine, Holocrine
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Gland structure: simple
1)Tubular 2)Coiled Tubular 3) Branched Tubular 4) Alveolar 5) Branched Alveolar
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3 types of Gland structure; Compound/Complex
1) Tubular 2) Alveolar 3) Tubuloaveolar
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3 basic components of Connective Tissues
1)specialized cells 2)Extracellular protein fibers 3)Fluid know as ground substances
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Connective tissue 4 key functions
1) Establishes structural framework 2)Transporting fluid and dissolved materials 3) protection 4) support
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3 types of connective tissue
1) Connective tissue proper 2) Fluid connective tissue 3) supporting connective tissue
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Mesenchymal Cells
Stem cells that are in connective tissue (respond to injury)
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Melanocytes
Contains melanin
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Mast cells
Contain histamine
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3 Types of fibers
1)Collagen (tendons and ligaments) 2) Reticula (stroma) 3) Elastic
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Membranes
Cover and protect other structures, made of epithelial and connective tissues
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4 Types of Membranes
1)Mucus 2)serous 3)cutaneous 4)synovial
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Mucus membrane
Line cavities that communicate with the exterior of the body
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Serous membrane
Line sealed internal divisions of the body
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Cutaneous
Covers the surface of the body
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2 responses to injuries
- 1) Inflammatory responses- Swelling, redness and pain
- 2) Regeneration- Isolation and repair
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Integumentary system: 2 components
1) Cutaneous membrane 2) Accessory structures
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Cutaneous Membrane made up of
Epidermis (superficial) Dermis (underlying) and Hypodermis (separates form organs)
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6 key functions of Integument
1) Protection 2) Excretion 3) Maintenance 4) Synthesis of vitamin D 5) detection 6) storage
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Cutaneous membrane: Epidermis
Provides mechanical protection and prevents microorganisms from getting inside the body
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Epidermis consists of 5 layers
- 1)stratum Germinatum
- 2)stratum Sinosum
- 3)stratum Granulosum
- 4)stratum Lucidum
- 5)stratum Corneum
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Basal cell
Germinave Cells (stem cells)
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Merkel cells
only where there is no hair (sensitive to touch)
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Stratum spinosum
- 8-10 layers
- Contains Langerhans cells- parcipate in immune response
- Stimulate defenses- against microorganisms, superficial skin cancers
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Keratinization
Cells filled with keratin
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Skin color
1) pigments 2) blood supply
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Carotene
Pigment- Orange, yellow color (accumulates in epidermal cells)
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Melanin
Pigment- Brown, yellow- Brown, black (proactive from UV radiation)
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Vitamin D3 (cholecalciferol)
- 1)Skin produces vitamin D3 due to sunlight
- 2)In the liver and Kidneys
- 3)Converted into calcitrol
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Glands: Exocrine Glands
1) Sebaceous 2) Sweat
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Holocrine
Produce oil-lipids
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sebum
secretion of lipids
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Sweat Glands 2 types
1) Apocrine 2) Merocrine
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Merocrine functions (3)
1) cooling 2) Excretion 3) Protection
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4 steps of repair
- 1) Bleeding and inflammation
- 2) Scab formation
- 3) Epidermal Cells fill in the space underneath the scab
- 4) Scab is shed
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Aging steps 1-5
- 1) Epidermis thins- Germinating cell activity declines
- 2) Number of Langerhans cells decrease
- 3) vitamin D production declines 75 %
- 4) Melanocyte activity declines
- 5) Glandular activity declines
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Aging steps 6-10
- 6) Blood supply reduced
- 7) hair follicles stop functioning
- 8) Dermis Thins
- 9) body fatt distribution stops
- 10) skin repairs slow
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3 types of secretion (may not need to know)
1) Serous Glands 2) Mucus glands 3) Mixed Exocrine Glands
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