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Blood
Fluid circulating through the heart, arteries, capillaries & veins, transporting oxygen & nutritive materials to the tissues
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Formed elements
Blood cells
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Plasma
Liquid portion of blood that carries formed elements, clotting factors, minerals & proteins
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Serum
Liquid portion of blood after removal of clotting factors & blood cells
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Bone marrow
Soft tissue within bone, with multiple function including production of blood cells
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Erythropoietin (EPO)
Hormone released by kidneys that stimulates red blood cell production in bone marrow
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Hematopoiesis
Formation of blood cells & other formed elements
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Spleen
Vascular lymphatic organ responsible for filtering blood, destroying old red blood cells, producing red blood cells before birth & storing blood
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Erythrocyte (red blood cell) (RBC)
Blood cell that carries oxygen & carbon dioxide
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Hemoglobin
- HGB
- Hb
- Hgb
- Protein in red blood cells that binds to oxygen & gives RBCs characteristic color
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Iron
- Fe
- Essential trace element necessary for hemoglobin to transport oxygen on RBCs
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Rh factor
Protein substance present in RBCs of most people (85%) capable of inducing intense antigenic reactions
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Leukocyte
- White blood cell
- WBC
- Largest blood cell, protects against pathogens, foreign substances & cell debris
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Granulocyte
White blood cell with visible granules, 3 types named according to type of dye each is attracted to
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Neutrophil
Granulocyte that fights against bacterial infections (stains neutral pink)
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Eosinophil
Granulocyte that function in allergic reactions & against parasites (stains red)
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Basophil
Granulocyte that releases histamine in allergic reactions & inflammatory responses (stains dark blue)
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Agranulocyte
WBC without clearly visible granules
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Lymphocyte
Type of agranulocyte that circulates in lymphatic system & is active in immunity
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B Lymphocyte
- B cell
- WBC that when in contact with a foreign antigen, produces antibodies to inactivate the antigen
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T Lymphocyte
- T cell
- WBC that matures in thymus & specializes in creating an immune response
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Macrophage
Enlarged & matured monocytes active in phagocytosis
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Thrombocyte
- Platelet
- PLT
- Cell fragments in blood that stick together to form a clot
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Clotting factors
Any of various plasma components involved in clotting process
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Coagulation
Clotting, changing from a liquid to solid state
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Fibrin
Elastic fiber protein needed in clotting & produced by fibrinogen
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Fibrinogen
Plasma protein that is converted into solid threads called fibrin
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Antigen
Agent or substance that provokes an immune response
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Antibody
- Ab
- Soldier-like cell that protects the body & inactivates antigens, provides immunity against specific organisms
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Histamine
Substance released by damaged cells that increases blood flow to area, causing inflammatory process involving heat, redness, swelling & pain
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Immunity
Protection against disease
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Pathogen
Any virus, microorganism, or other substance that causes disease
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Phagocytosis
Cellular process of eating & destroying substances, usually by the neutrophils & macrophages
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-emia
Blood (condition of)
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-lysis
Destruction, breakdown, separation
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-poiesis
Production, formation
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Autoimmunity
- Pertaining to one's immune system attacking its own tissues or cells
- Note: Pt = Pertaining to
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Cytopathic
Pt disease or disorder of cell or cellular component
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Hematopoietic
Pt formation of blood cells
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Hemolytic
Pt rupture or destruction of RBCs
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Hemorrhagic
Pt profuse or excessive bleeding
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Hemostasis
Stoppage or arrest of bleeding
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Hypersensitive
Condition of excessive response or exaggerated sensitivity to stimulus
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Inflammatory
Pertaining to process of heat, redness, swelling & pain, in response to tissue injury
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Predisposition
Condition of being susceptible to disease
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Proliferative
Growing & increasing in number of similar cells
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Rejection
Immunologic response of incompatibility to transplanted organ or tissue
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Systemic
Pertaining to body as a whole
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Virulent
Denotes an extremely toxic pathogen
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Anemia
Condition in which number of RBCs, hemoglobin or volume of packed cells is lower than normal
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Aplastic anemia
Disorder in which bone marrow does not produce enough RBCs
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Iron deficiency anemia
Disorder where hemoglobin is unable to transport oxygen due to lack of iron
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Pernicious anemia
Disorder where number of RBCs decline with simultaneous enlargement of individual cells due to inability to absorb vitamin B-12 (usually in older adults)
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Hemorrhagic anemia
- blood loss anemia
- Disorder where lack of RBCs due to profuse blood loss
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Thalassemia
Disorder where genetic defect resulting in low hemoglobin production
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Sickle cell anemia
Disorder where genetic defect resulting in abnormal hemoglobin causing sickle-shaped RBCs that have a hard time moving through small capillary vessels
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Autoimmune disease
Condition in which immune system attacks normal body tissues
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Clotting disorder
Condition of inability of blood to coagulate
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Hemophilia
Bleeding disorder due to deficiency of clotting factor
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Thrombocytopenia
Disorder involving low levels of platelets in blood
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Idiopathic thrombocytopenic purpura
- ITP
- Disorder marked by platelet destruction by macrophages resulting in bruising & bleeding from mucous membranes
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von Willebrand disease
- vWD
- Bleeding disorder characterized by tendency to bleed primarily form mucous membranes due to deficiency of clotting factor
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Hemochromatosis
Excessive absorption & storage of dietary iron in body tissues causing dysfunction
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Mononucleosis
Increase of mononuclear leukocytes with symptoms of fever, enlarged cervical lymph nodes & fatigue
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Pancytopenia
Deficiency in all types of blood cells
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Polycythemia
Increase of RBCs
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Rheumatoid arthritis
- RA
- Autoimmune disease causing progressive destructive changes & inflammation in multiple joints, especially in hands & feet
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Septicemia
Spread of microorganisms or toxins through circulating blood
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Siogren syndrome
Chronic autoimmune disease in which a person's WBCs attack their moisture-producing glands
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Systemic lupus erythematosus
- SLE
- Inflammatory, autoimmune, connective tissue disease that can affect all organ systems
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Thrombosis
Abnormal presence of clotting within a blood vessel
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Albumin
Measurement of protein level, used to diagnose liver or kidney problems, inflammation, malnutrition or dehydration
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Bilirubin
Screen for liver disorders or anemia
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Blood smear
Evaluation of appearance & number of blood cells & different types of WBCs
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Complete blood count
- hemogram
- CBC
- Automated count of all blood cells
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Erythrocyte sedimentation rate
- ESR
- Time measurement of RBCs settling in test tube over 1hr, used to diagnose inflammation & anemia
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Hematocrit
- HCT
- Hct
- Volume of blood occupied by RBCs, used to diagnose various disorders including anemia
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Hemoglobin test
Test for RBC protein responsible for binding oxygen, used to diagnose various disorders including anemia
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Platelet count
- PLT
- Number of platelets present, used to diagnose bleeding disorders or bone marrow disease
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Red blood cell count
Number of erythrocytes present, used to diagnose various disorders including anemia
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White blood cell count
Number of leukocytes present, used to diagnose various disorder, including infection & diseases, and for monitoring treatment
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Cross-matching
Blood typing test for compatibility between donor & recipient blood
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Culture & sensitivity
- C & S
- Blood typing test for compatibility between donor & recipient blood
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Prothrombin time
- PT
- Measurement of time for blood to clot
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WBC differential count
- differential count
- Evaluation of total percentage of leukocytes
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Antinuclear antibody test
- ANA test
- Assessment for autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis & others
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Epstein-Barr virus antibody test
- EBV antibody test
- Diagnostic test for mononucleosis & evaluation of Epstein-Barr virus
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Mononucleosis spot test
Assessment for mononucleosis
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Rheumatoid factor test
Test for rheumatoid arthritis & Sjogren syndrome
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Apheresis
Removal & replacement of patient's own blood or donor blood after specific components have been removed
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Blood transfusion
- BT
- Transfer of blood between compatible donor & recipient
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Autologous blood
Blood donated for future use by same patient, usually pre-surgical
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Homologous blood
Blood donated from same species for use by compatible recipient
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Blood component therapy
Transfusion of specific blood components such as packed RBCs, plasma or platelets
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Bone marrow aspiration
- BMA
- Removal of small amount of fluid & cells from inside bone with needle & syringe
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Immunization
- Vaccination
- Administration of weakened or killed pathogen or protein of pathogen, to cause immune system to create antibodies for future protection
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Immunosuppression
Use of chemotherapy or immunosuppressant drugs to interfere with immune responses, usually prescribed for autoimmune disorders
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Plebotomy
- Venipuncture
- Venotomy
- Incision into vein to inject a solution or withdraw blood
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Plasmapheresis
Removal & replacement of patient's own blood after plasma has been removed & replaced with plasma substitute
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Splenectomy
Surgical removal of spleen
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Antibiotic
Drug that acts against susceptible microorganisms
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Anticoagulant
Drug to prolong blood clotting time
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Antihistamine
Drug to stop effects of histamine
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Hemostatic agent
- Procoagulant
- Drug that stops flow of blood within vessels
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Immune serum
Serum prepared form individual with specific disease antibodies
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Immunosuppressant
Drug used to suppress or reduce immune responses in organ transplant recipients or those with severe autoimmune diseases
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Thrombolytic agent
Drug that dissolves a blood clot
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Vaccine
Preparation composed of weakened or killed pathogen
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Allergology
Medical specialty concerned with diagnosis & treatment of allergy & sensitivity
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Allergist
Physician who specializes in allergology
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Hematology
Medical specialty concerned with diagnosis & treatment of disorders of blood & blood-forming organs
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Hematologist
Physician who specializes in hematology
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Immunology
Medical specialty concerned with immunity, allergy & induced sensitivity
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Immunologist
One who practices immunology
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Rheumatology
Medical specialty concerned with diagnosis & treatment of rheumatic conditions & autoimmune diseases
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Rheumatologist
Physician who specializes in rheumatology
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ANA
Antinuclear antibody test
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BMA
Bone marrow aspiration
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BMT
Bone marrow transplant
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C&S
Culture and sensitivy
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ESR
Erythrocyte sedimentation rate
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ITP
Idiopathic thrombocytopenic purpura
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PLT
Platelet or platelet count
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SLE
Systemic lupus erythematosus
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vWD
von Willebrand disease
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WBC
White blood cell/count
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