ClinMedV:Toxicology (Anticoag Rodenticides)

  1. Rodenticides antagonize what that is important to coagulation ability?
    vitamin K
  2. What does blocking vitamin K ultimately inhibit?
    • prothrombin factor II
    • also factors VII XI and X
  3. What should you try to do?
    bring in package because tx differs from first to second generation of product
  4. Although uncommon how else can pets get rodenticide toxicity?
    ingestion of rats
  5. Symptoms can sometimes be vague with rodenticide toxicity and may not present til
    2-7 days after ingestion
  6. The symptoms are related to bleeding and include:LVPPBMEDHHS
    • lethargy
    • v+
    • pale mm
    • petechia
    • bruising
    • melena
    • epistaxis
    • dypsnea
    • hemothorax
    • hematuria
    • sudden death
  7. dx is made based off of:HSBCPP
    • hx
    • symptoms
    • blood work
    • clotting test-prothrombin time(PT) and partial prostothrombin time(PTT)
  8. tx includes:IAVCT
    • induce voming
    • activated charcoal
    • vitamin K1 (best if oral)
    • cathartic
    • transfusion
  9. How long should vitamin K tx continue?
  10. What test is given before and after finishing meds?
  11. The PIVKA tests for _ induced by vitamin K antagonism
  12. The PIVKA looks for what accumulated in circulation?
    inactive precursors
  13. The PIVKA detects a deficiency in what clotting factors?
    • II
    • VII
    • X
  14. What is checked 2 days post ingestion and then 2 days after finishing vit K?
    PT (prothrombin time)
Card Set
ClinMedV:Toxicology (Anticoag Rodenticides)