ClinMedV Toxicology (NSAIDS)

Brand name for acetaminophin:

Tylenol
Who has a low tolerance for acetaminophen where 1 dose can kill?

cats
What can happen to dogs with acetaminophen?

less sever than cats, but liver damage or failure at toxic doses
Toxic dose of acetaminophen in the dog.

160-600mg/kg
Toxic dose of acetaminophen in the cat.

50-60mg/kg
Clinical signs of acetaminophen are seen within 1-2 hours. What are they?ADVDCB/MDF
- anorexia
- depression
- v+
- dypsnea
- cyanosis
- brown mm/ methemogobinemia
- dark urine
- facial edema
When is death seen for acetaminophen toxicity?

1-2d
Cats can't biotransform acetaminophen because of reduced ability to conjugate....

glucuronic acid
dx of acetaminophen toxicity

based on hx and evidence of liver failure
tx acetaminophen toxicity:EGSAA
- emesis
- GI decontamination
- supportive care
- acetylcysteine
- ascorbic acid
Acetylcysteine is a what stimulator?

glutathione
what does acetylcysteine do?

acts as alternative substrate for conjugation and detoxification of acetaminophin
In general NSAIDS have what effect?

liver and kidney side effects
dx of nsaid tox
- hx
- bw
Name some GI protectants used to to treat NSAID tox:SC
- sucralfate
- cimetidine

Author

heather.dundas

238598

Card Set

ClinMedV Toxicology (NSAIDS)

Description

vti

Updated

2013-10-03T20:37:17Z

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