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Appositional growth in elastic cartilage
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Fibrocartillage, fibroblasts indicated by arrow, and isogenic group in high mag
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Fibrocartilage. C, chondrocyte; F, fibroblast.
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Chondrocytes in fibrocartilage. Wavy bundles of fibers are type I collagen. Cartilage matrix (type II collagen) is immediately around the chondrocytes. X700.
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EM of fibrocartilage-3 chondrocytes in their lacunae. Note the abundance of rough endoplasmic reticulum. Chondrocytes synthesize the cartilage matrix. Fine collagen fibrils, sectioned in several places, are found around the chondrocytes and at the lower left side of the image. x3750.
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Fibrocartilage—don’t see the fibroblasts, only the chondroblasts visible
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Chondrogenesis-Blastema formation from mesenchyme cells which will form a chondroblast
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- Mesenchyme cells differentiate into chondroblasts which in turn give rise to chondrocytes. Note the perichondrium surrounding the growing cartilage.
- Future perochondrium surrounding the blastema
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- Embryonic hyaline cartilage surrounded by the perichondrium. Embryonic connective tissue (mesenchyme) is found outside the perichondrium.
- Note absence of BVs in mesenchyme but there are other BVs in the other areas
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growing cartilage surrounded by perichondrium
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interstitial cartilage growth
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- Example of the cartilage interstitial growth. A. chondrocytes undergoing mitotic division.
- Note that immediately after division, daughter cells are found within the same lacuna (dashed line).
- B, later, daughter cells are separated from each other by the secretion of the extracellular matrix.
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old chondrocytes and osteoarthritis
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Trachea and esophagus. Note replacement of tracheal cartilage with bone
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- Tracheal ring from elderly person. Darker
- cartilage is normal matrix. Lighter more
- eosinophilic areas are bone tissue (B) which has replaced the original cartilage. Marrow cavity has formed in the original cartilage structure. Red star= marrow
- cavity X 75
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Trachea. Cartilage replacement by bone. Asterisk = Bone marrow
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- CC—cartilage canal, P—perichondrium
- B: Cross section of CC
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