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3 functions of connective tissue?
- Support and connect different tissues
- maintain water required for metabolism
- Allow diffusion of nutrieints to different tissues
Is connective tissue made mainly with cells?
No mostly ECM but cells are there
The connective tissue found in organs is reffered to as? And supports the organs functional tissue or?
The ECM of connective tissue is composed mostly of what?
- Large protein fibers
- Non fibrous areas of ground substance
All adult connective tissue is derived embryonically from?
mesenchyme which contains undifferentiated stem cells scattered in a gel like mix
What are 5 cells of the connective tissue? Describe each briefly. What other kinds of immune cells can you find in connective tissue?
- Fibroblasts - synthesize and secrete most components of the ECM
- Adipocytes - very large cells specialized for storage, often found in special connective tissue, adipose tissue
- Macrophages - short lived, differentiate in connective tissue, Function as ECm turnover, phagocytosis of dead cells and debris, and antigen presentation
- Mast cells - Filled with granules, inflammatory and allergic reactions
- Plasma cells - Short lived cells, differentiate from B lymphocytes and are specialized for abundant secretion of specific antibodies
Other leukocytes normally wander these tissues
what are the most importantconnective tissue fibers?
Who produces collagen?
Postranslational modifications of collagen occur in the? These include?
hydroxylation and formation of trimeric procollagen
When procollagen is exocytosed what happens to it for it to become trimeric collagen?
- terminal subunits are removed
- They then bind together to begin forming collagen fibrils
What pattern do we see in collagen fibers? Why?
Cross banding, because highly regular assembly and regular occurrence of spcaes between trimeric collagen bundles
What helps bundle together collagen?
Non fibrillar linking collagens
What produces the primary degrader of collagen? What is it?
- collagenase (classified as metalloproteinases)
Type 3 collagen produces? Which stains darkly with? and is found in?
- reticular fibers
- immune and lymphoid tissues
What is a technical name of elastic sheets?
Does ground substance stain well?
Sulfated GAGs are produced where?
In the golgi
What attached proteoglycans to HA?
What are the major types of GAGs?
- Hyaluronic acid (HA)
- shorter sulfated GAGs
What is the purpose of multiadhesive proteins? give 2 examples
- Give binding sites for collagen on cell membranes thus allowing attachment between cell and ECM
How is connective tissue proper classified in terms of density
What is another name for loose connective tissue?
Where do we most often see loose connective tissue?
- Small blood vessels and adjacent to epithelia
- Significantly more ground substance
What composes dense irregular connective tissue?
- Bundles of type 1 collagen
- elastic fibers
Where do you find dense regular connective tissue?
Tendons and ligaments
Where are you most likely to find mucoid tissue? What is this?
- Around small blood vessels or the umbilical chord
- embryuonic form of connective tissue, gel like, few cells, resembles mesenchyme