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Metabolism
all the chemical reactions in the body
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Catabolism
- breakdown of complex organic molecules
- release stored energy
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Anabolism
- combine simple molecules to form complex molecules
- require energy
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ATP
- is NOT energy it just transports it
- is an energy coupling agent
- not a fuel
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Energy Coupling
energy released by 1 set of reactions is almost immediately consumed by another
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Energy is release from ATP when?
When the 3rd phosphate bond is broken turning it back to ADP
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Oxidation
- removal of electrons
- results in decreases in energy content
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Reduction
- addition of electrons
- results in increase in energy content
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" OIL RIG"
- Oxidation Is Loss
- Reduction Is Gain
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Coenzymes
NAD & FAD temporarily hold enzymen then release them
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Aerobic respiration
presence of oxygen
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Anaerobic respiration
absence of oxygen
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Aerobic Cellular Respiration
- 4 steps
- Glycolysis
- Formation of acetyl coenzyme A
- Krebs cycle
- Electron transport chain
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What happens in the 1st step
Glycolysis
oxidize 1 6-carbon molecule of glucose into 1 3-carbon molecules of pyruvate in a series of smaller steps called Glycolysis
- Occurs in the cytoplasm
- 02 not required
- outside of the Mitochondria
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What happens in the 2st step
Formation of Acetyl
- if sufficient oxygen present acetyl is formed from splitting pyruvic acid
- 3-carbon
- Pyruvic acid
- 2-carbon
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What happens in the 3rd step
Krebs Cycle
Acetyl diffuses into the ,matrix of the mitochondria
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What happens in the 4th step
Electron Transport Chain
series of 3 electron carriers known as CYTOCHROMES which are embedded within the inner mitochondrial membrane
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CYTOCHROMES
series of 3 electron carries they are imbedded in the mitochondria membrane
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Oxygen is the final what?
O2 is the final electron acceptor
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Tight Junctons
- found where leakproof seal are needed between cells
- (Ie: stomach and bladder)
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Adheren Junctions
- adhesion belt prevents tissues from separating as they stretch and contract
- (Ie: intestinal epithelium)
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Desmosome
- Act as "spot welds"
- found in the heart and epidermis
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Hemidesmosomes
are half welds- join cells to the basement membrane
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Gap Junction
are pores that allow water and small substance like ions to pass between cells
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Simple Squamous Epithelium
found where large amounts of fluid or gas need to pass through quickly
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Simple Cuboidal Epithelium
often found ling the tubules of the kidneys and glands
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Simple Columnar Epithelium
- can be found lining the intestines
- have Goblet cells
- Microvilli increase surface area for absorption
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Cilia
- beat in unison to move mucous, foreign particles, or large cells
- (Ie: bronchioles, fallopian tubes)
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Transitional Epithelium
- found only in the urinary bladder
- apical "dome cells" of the top layer signify an empty bladder while the cells are flattened in a fuller bladder
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Endocrine glands
- ductless- do not have ducts to convey secretion
- Secretions enter directly into adjacent blood vessels and are transported throughout the body in blood
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Exocrine glands
ducts convey the secretions to the surface of skin, lumen, or other open surface
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Categorize multicellular glands according to function based in manner of secretion to the outside environment
- Merocrine
- Apocrine
- Holocrine
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Merocrine
- secretion is the most common
- releases production by exocytosis, no part of the gland is lost or damaged
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Apocrine
- glands "bud" off secretions
- end of cell breaks off
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Holocrine
releasing entire cellular contents into the lumen and killing the cell
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Carcinoma
cancer derived from epithelium
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