1. Belladona Source
    • dried leaf and flowering/fruiting top of Atropa belladonna
    • perennial herb indigenous to C. and S. Europe and cultivated through the rest of the temperate or subtropical world
    • major sources: Balkans and Henbane
  2. Belladona Color
    white, crystalline
  3. chemical structure of S-Hyoscyamine
    • contains tropane ring and teritary amine
    • equatorial methyl is favored
  4. scopolamine structure
    • tropane ring
    • epoxide ring
    • axial methyl favored
  5. first product in tropane alkaloid biosynthesis
  6. belladonna alkaloid PD receptor
    • antagonize M1-M5 muscarinic receptors
    • nonselective
    • no effect at nicotinic receptors
  7. belladonna alkaloids and GI
    • inhibit motility
    • decrease tone, amplitude, and frequency of peristaltic contractions
    • antisecretory (xerostomia)
  8. belladonna alkaloids and genitourinary
    • dilates pelves, calyces, and reters
    • decrease tone and amplitude of contracitons of the rureters and bladder
    • promote urinary retention
    • inhibits penile erections (inhibits vasodilation)
  9. belladonna alkaloids and CV
    blocks vagal inhibiton at sinoatrial node - tachycardia
  10. belladonna alkaloids and CNS
    • stimulate medulla and higher cerebral centers
    • disorientation, delirum, hallucinations, medullary depression, coma, death
  11. scopolamine and CNS
    produces CNS depression at therapeutic doses
  12. source of scopolamine
  13. production of ipratropium
    quaternization of tertiary nitrogen atom of atropine with isopropyl bromide
Card Set
Pulm, Schiff