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- Mast cells releasing histamine
- Blebbing of outside of cell is granules
- being released.
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Mast cells and macrophages, lithium-carmine injection; toluidine blue
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- A-nucleus of mast cell
- B-cytoplasmic granules of mast cell
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Mast cells near blood vessels (red arrows), skin rat, neutral red. Whole mount slide
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- A-muscle cell
- B-5 mast cells
- C- blood vessel
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- LM image of Kupffer Cells (black cells), sinsoids are white areas
- Kupffer are liver macrophages
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Macrophage-langhan's cell
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- Langhans’ Cell. Note the horseshoe arrangement of the nuclei.
- Red arrow, fused nuclei
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- A-macrophage
- B-eosinophil
- Electron micrograph of several macrophages and 2 eosinophils in a region adjacent to a tumor. This figure illustrates the participation of macrophages in tissue reaction to tumor invasion.
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macrophage in spleen of dog
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- A- RBC
- B-fenestrated sinusoid
- C-arm of macrophage
- SEM of a macrophage cytoplasmic process in rat liver. A macrophage (kupffer’s cell) extends a cytoplasmic process in recognition of a damaged (previously fixed in glutaraldehyde for a few minutes) erythrocytes in the initial stage of phagocytosis.
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- A-lymphocyte
- B-macrophage
- Red arrow- contact between lymphocyte and macrophage
- Electron micrograph of a macrophage. Note the lysosomes (L), the nucleus (N), and the nucleolus (Nu). The arrows indicate phagocytic vacuoles.
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- Phagocytosed material is destroyed by the
- action of lysosomes.
- The end product of digestion is either recycled or exocytosed.
- Inert particles like inhaled carbon will resist digestion and may remain in the cytoplasm indefinitely as residual bodies
- P=phagolysosome, L=lysosome
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- A-early endosome
- B-lysosomes
- TEM of macrophage exhibiting endocytotic vesicles, early and late endosomes, lysosomes, and phagolysosomes. X 10,000.
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When macrophages take up massive amounts of cholesterol they form “foam cells,” characterized by multiple lipid droplets (stained red).
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Section of pancreas from a rat injected with the vital dye trypan blue. Note that 3 macrophages (arrows) have engulfed and accumulated the dye in the form of granules. H&E stain. Low magnification. Darker spots are lysosomes found within the macrophages
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- Arrows to bundles of actin in cytoplasm.
- Fatter arrows to collagen fibrils
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connective tissue layer (dermis) shows several fibroblasts (F), which are the elongated cells. H&E stain. Medium magnification.
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Quiescent fibroblasts are elongated cells with thin cytoplasmic extensions and condensed chromatin. Pararosaniline-toluidine blue (PT) stain. Medium magnification.
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- A- fibroblast
- B-Collagen
- C-cytoplasmic extension
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