-
Stress and panic
Locus ceruleus
-
Reward center, pleasure, addiction, fear
Nucleus accumbensand septal nucleus
-
Ventral tegmentum and SNc
Dopamine
-
Basal nucleus of Meynert
ACh
-
area postrema
responds to emetics
-
supraoptic nucleus of hypothalamus
ADH
-
paraventricular nucleus of hypothalamus
oxytocin
-
lateral area of hypothalamus
hunger - inhibited by leptin
-
ventralmedial area
satiety - stumulated by leptin
-
anterior hypothalamus
cooling, parasympathetic
-
posterior hypothalamus
heating, sympathetic
-
septal nucleus
sexual urges
-
Lateral geniculate nucleus
visual
-
medial geniculate nucleus
auditory
-
ventral posterior nucleus - lateral (VPL)
body sensation
-
ventral posterior nucleus - medial (VPM)
facial sensation
-
ventral anterior/lateral (VA/VL)
motor
-
Five F's of the limbic system
- Feeding
- Fleeing
- Fighting
- Feeling
- Sex
-
Important for voluntary movements and making postural adjustments
Basal ganglia
-
resting Tremor, cogwheel Rigidity, Akinesia, and Postural instability
Parkinson's Disease
-
Contralateral subthalamic nucleus lesion - lost of inhibition of the thalamus throug globus pallidus
Hemiballismus
-
Caudate losses ACh and GABA (CAG)
Huntington's - Chromosome 4
-
treatment for essential/postural tremor
beta-blockers - action tremor worses when holding posture,AD
-
Intention Tremor
cerebellar dysfunction
-
Kluver-Bucy syndrome (hyperorality, hypersexuality, disinhibited behavior)
Amygdala
-
Spatial neglect syndrome (angosia of the contralateral side of the world)
Right parietal lobe
-
reduced levels of arousal and wakefulness
reticular activating system (midbrain)
-
Wernicke-Korsakoff syndrome
mammillary bodies (bilateral)
-
truncal ataxia, dysarthria
cerebellar vermis
-
contralateral hemiballismus
subthalamic nucleus
-
anterograde amnesia - inability to make new memories
Hippocampus
-
eyes look away from side of lesion
Paramedial pontine reticular formation (PPRF)
-
Eyes look toward lession
Frontal eye fields
-
cricothyroid muscle is supplied by the:
external branch of the superior laryngeal nerve
-
Charcot-Bouchard microaneurysms is associated with
Chronic hypertension
-
Wet, wobbly, and wacky (urinary incontinence, dementia, ataxia)
normal pressure hydrocephalus - does not result in increase in subarachnoid space volume
-
destruction of anterior horns leading to flaccid paralysis
poliomyelitis and Werdnig Hoffman disease
-
degeneration of dorsal roots and dorsal columns
tabes dorsalis (tertiary syphilis)
-
damages to the antieor white commissure
- Syringomeylia - destroys spinothalamic tract, bilateral loss of pain and temperature sensation
- Seen with Arnold-Chiari II
-
Dorsal columns and lateral corticospinal tracts and spinocerebellar tracts
Vitamin B12 neuropathy, Vitamin E deficiency, and Friedreich's ataxia
-
"floppy baby" with tongue fasciculations - infantile spinal muscular atrophy
Werdnig-Hoffman disease (similar to Poliomyelitis)
-
Defect in superoxide dismutase 1 can cause:
ALS
-
melatonin secretion, circadian rhythms
pineal gland
-
conjugate vertical gaze center
superior colliculi
-
auditory
inferior colliculi
-
paralysis of conjugate vertical gaze due to lesion in superior colliculi
parinaud syndrome
-
Send autonomic (paraysympathethic) fibers to heart, lungs, and upper GI
Dorsal motor nucleus
-
Motor innervation of pharynx, larynx, and upper esophagus
Nucleus aMbiguus - IX, X, XI
-
CN I exits
cribriform plate
-
-
CN III, IV, V1, VI exits
Superior orbital fissure
-
CN V2 exits
Foramen Rotundum
-
CN V3 exits
Foramen Ovale
-
Middle meningeal artery exits
Foramen Spinosum
-
CN VII, and VIII exits
internal auditory meatus
-
CN IX, X, XI and jungular vein exits
Jugular foramen
-
CN XII exits
Hypoglossal canal
-
Spinal roots of CN XI, brain stem, vertebral arteries
Foramen magnum
-
Kuh-Kuh-Kuh
palate elevation - CN X
-
-
-
Muscles of mastication are innervated by:
V3
-
lateral pterygoid
Not one of the M's, so OPENS the jaw
-
palatoglossus muscle is innervated by:
Vagus nerve
-
All other glossus muscles are innervated by:
hypoglossus - CN XII
-
tensor veli palatini is innervated by:
mandibular branch - V3
-
All muscles with palat in their names are innervated by:
vagus nerve
-
ciliary muscle contracts
near vision
-
Classic galactosemia, galactokinase deficiency, and diabetes all can develop:
cataracts
-
decrease bilateral pupillary constriction when light is shone in affected eye (no consensual constriction)
Marcus Gunn pupil - afferent pupillary defect
-
What is affected first during compression of the oculomotor nerve?
parasympathetic output - use Marcus Gunn pupil to assess
-
lesion in the medial longitudinal fasciculus is often seen with?
Multiple Sclerosis
-
ApoE2 is protective in what condition?
Alzheimer's
-
Dementia, aphasia, parkisonian aspects and a change in personality with intracellular aggregated tau proteins
Pick bodies
-
alpha-synuclein defect can be found in what condition with hallucinations and parkinsonism?
Lewy body dementia
-
Beta-interferon or immunosuppression therapy can be used in what condition?
Multiple Sclerosis
-
Progressive multifocal leukoencephalopathy
JC virus usually with AIDS patients
-
Arylsulfatase A deficiency is linked to
Metachormatic leukodystrophy - AR lysosomal storage disease - impaired production of myelin sheath
-
butterfly glioma positive for GFAP in adults
Glioblastoma multiforme
-
Psammoma bodies in the brain
meningioma
-
S-100 posiive
schwannoma - usually found at the cerebellopontine angle
-
chicken-wire capillary pattern in the frontal lobes
oligodendroglioma
-
GFAP positive in kids with Rosenthal fibers (eosinophilic corskscrew fibers)
Pilocytic astrocytoma
-
Small blue cells with rosettes or perivascular pseduorosette pattern of cells
Medulloblastoma
-
rod-shaped blepharoplasts
ependymoma
-
Can produce EPO causing secondary polycythemia
hemangioblastoma
-
darkening brown color of iris is a side effect of:
Latanoprost (PGF2alpha)
-
A weak opioid agonist that decreases seizure threshold
Tramadol
-
induction of anesthesia and short surgical procedures
barbiturates - thiopental
-
endoscopy - anesthetic:
midazolam
-
anesthetic that causes disorientation, hallucination, and bad dreams
arylcycloheyxlamines (ketamines)
-
Which local anesthetic causes severe cardiovascular toxicity
bupivacaine
-
Which local anesthetic can cause arrhythmias
cocaine
-
Complication of succinylcholine are:
Hypercalcemia and Hyperkalemia
-
use of inhalation anesthetics and succinylcholine can cause:
malignant hyperthermia
-
malignant hyperthermia and neuroleptic malignant syndrome can be treated with
dantrolene
-
what drug used to treat Parkinson's should be avoided in patients with BPH and angle-closure glaucoma?
Benztropine
-
Which MAO-B inhibitor selectively metabolizes DA over NE and 5-HT?
Selegiline
-
Which NMDA receptor antagonist is used to treat alzhemier's?
memantine
-
Donepezil, galantamine, rivastigmine are all?
Acetycholinesterase inhibitors used to treat Alzheimer's
-
Reserpine and tetrabenazine can be used to treat?
Huntington's
-
haloperidol, a dopamine receptor antagonist can be used to treat?
Huntington's
-
What drug is countraindicated for patients with CAD or Prinzmetal's angina due to its toxic effect of causing coronary vasospasms
sumatriptan
-
What can precipitate psychosis?
L-dopa
-
Chronic factitious disorder
munchausen's syndrome
-
criminality is associated with
Anti-social disorder
-
sel-mutilation and sense of emptiness is associated with
Borderline personality disorder
-
A sensitive indicator of alcohol use is:
GGT levels
-
Treat Tourette's syndrome with:
Haloperidol
-
Side Effects of Lithium - LMNOP
- Lithium Side Effects
- Motor (tremors)
- Nephrogenic Diabetes Insipidus
- hypOthyroidism
- Pregnancy problems
-
This can be used for generalized anxiety disorders:
Buspirone
-
TCA toxicity causes: Tri-C's
- Convulsions
- Coma
- Cardiotoxicity
-
cyproheptadine can be used to treat:
Serotonin syndrome caused by SSRIs
-
duloxetine can be used to treat
Diabetic peripheral neuropathy
-
venlafaxine can be used to treat:
generalized anxiety disorder
-
venlafaxine and duloxetine are both:
SNRI's - serotonin & NE reuptake inhibitor
-
This atypical antidepressant can also be used for smoking cessation and causes no sexual side effects:
Bupropion
-
alpha2 antagonist and potent 5HT2 and 5HT3 receptor antagonist:
mirtazapine
-
Only blockes NE reuptake
Maprotiline
-
Phenelzine is what kind of drug?
MAO inhibitor!
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