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andresjm
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Name the typical antipsychotics
- haloperidol plus the -azines
- e.g. trifluoperazine, fluphenazine, thioridazine, chlorpromazine
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Antipsychotics: MOA
block DA D2 receptors to increase cAMP
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Name the atypical antipsychotics
Olanzaine, clozapine, quetiapine, risperidone, aripiprazole, ziprasidone
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Lithium: tox
- tremor sedation edema heart block
- hypothyroidism
- polyuria (NDI)
- Ebstein's anomaly (atrialized right ventricle)
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Buspirone: use and MOA
- GAD
- Stimulates 5-HT1A receptors
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name the TCAs
- imipramine, desipramine, clomipramine
- amitriptyline, nortriptyline
- doxepin, amoxapine
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TCAs: MOA
block NE and 5HT reuptake
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TCAs: tox and tx
- Convulsions Coma Cardiotox
- treat with NaHCO3 for CV tox
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SSRIs: name them
- fluoxetine
- paroxetine
- sertraline
- citalopram
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SNRIs: name them
- venlafaxine (GAD)
- duloxetine (neuropathy, greater NE effect)
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MAOis: name them
- phenelzine
- selegiline (B only)
- tranylcypromine
- isocarboxazid
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Buproprion: MOA
increase NE and dopamine via unknown mechanism
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Mirtazapine: MOA
- alpha2 antagonist increases NE and serotonin release
- 5HT2 and 3 receptor antagonist
- for depression
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Maprotiline: MOA
- blocks NE reuptake
- for depression
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Trazodone: MOA
- inhibits serotonin reuptake
- used for insomnia
- high doses needed for depression
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