-
Cyclosporine: MOA
Inhibits calcineurin to prevent IL-2 production (and therefore T cell activation)
-
Cyclosporine: toxicity
- Viral infections, lymphoma
- Nephrotoxic (prevent with mannitol)
-
Tacrolimus (FK506): MOA
- Similar to cyclosporine
- Binds to FK-binding protein inhibiting secretion of IL-2 and others
-
Tacrolimmus: toxicity
- Nephro, neuro
- HTN, pleural effusion, hyperglycemia
-
Azathioprine/6-MP: MOA
Interferes with nucleic acid synthesis
-
Azathioprine/6-MP: tox
- active metabolite mercaptopurine is metabolized by XO
- BM suppression
-
Muromonab-CD3 (OKT3)
Ab binding CD3 on T cell surface
-
Sirolimus/rapamycin: MOA
Binds mTOR to inhibit T cell prolif in reseponse to IL2
-
Sirolimus/rapamycin: tox
HLD, thrombocytopenia, leukopenia
-
MMF: MAO
Inhibits de novo guanine syntehsis
-
Daclizumab: MOA
Ab for IL-2 receptor on activated T cells
-
Aldesleukin
IL-2 for RCC and melanoma
-
Filgrastim
G-CSM for BM recovery
-
Sargramostim
GM-CSF for BM recovery
-
a-IFN uses
HBV, HCV, Kaposi's, leukemias, melanoma
-
-
-
Drugs for thrombocytopenia
- Oprelvekin (IL-11)
- Thrombopoietin
|
|
