Alpha-glucosidase inhibitors

Alpha-glucosidease inhibitors MOA
- inhibits action of intestinal amylase and alpha-glucosidase action
- causes delay in breakdown of complex carbs to glucose --> glucose absorbed in distal part of SI and peak postprandial bg conc reduced
alpha-glucosidase inhibitor affects fasting or post prandial?

post pranidal (decreases bg peak)
alpha-glucosidase inhibitors
- acarbose
- miglitol
alpha-glucosidase inhibitors metabolism and elimination
- metabolism: none
- acarbose elim: excreted in feces
- miglitol elim: unchanged; renally
when to take alpha-glucosidase inhibitor
- with first bite of each meal
- want the drug mixed with food to inhibit the enzyme
alpha-glucosidase inhibitor potency
- weak compared to other agents
- good for ppl with early disease (mildly elevated A1C -> normal FBG and high PPG)
alpha-glucosidase inhibitors and simple sugars

no effect
alpha-glucosidase inhibitor contraindication
- inflammatory bowl disease
- colonic ulceration
- partial intestinal obstruction
- other chronic intestinal diseases
alpha-glucosidase inhibitors side effects
- GI (gas, ab pain, diarrhea) --> reduce in 4-8 wks or with dose reduction
- inc in transaminases (dose related)
- hypoglycemia when used in combo
alpha-glucosidase inhibitor DDIs
- charcoal
- digestive enzymes

Author

jcu1

236089

Card Set

Alpha-glucosidase inhibitors

Description

Dr. Drab

Updated

2013-09-21T05:06:44Z

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