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What is the proteoglycan when the GAG is chondroitin sulfate?
What is its function?
- versican
- for cell-cell, cell-matrix interaction
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What is the proteoglycan when the GAG is chondroitin sulfate and keratan sulfate?
What is its function?
- aggrecan
- hydration of the ECM cartilage
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What is the proteoglycan when the GAG is dermatan sulfate?
What is its function?
- decorin
- collagen fibrogenesis, fiber orientation, regulates thickness of fibrils and interact with TFG-beta
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What is the proteoglycan when the GAG is heparan sulfate?
What is its function?
- syndecan
- cell-EMC interaction
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What GAG makes up the proteoglycan versican?
What is the function of versican?
- chondroitin sulfate
- cell-cell, cell-matrix interation
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What GAG make the proteoglycan aggrecan?
What is its function?
- chondroitin sulfate and keratan sulfate
- hydration of ECM of cartilage
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What GAG make the proteoglycan decorin?
What is its function?
- derman sulfate
- collagen fibrogenesis, fiber orientation, regulates thickness of fibril and interact with TFG-beta
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What is the GAG that made syndecan?
What is syndecan's function?
- heparan sulfate
- cell-EMC interaction
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What GAG is predominant in cartilage and synovial fluid?
hyaluronic acid
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In what tissue is hyaluronic acid abundant?
cartilage and synovial fluid
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In what tissue is chondroitin sulfate abundant?
bone and cartilage
-
What GAG is abundant in bone and cartilage?
chondroitin sulfate
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In what tissue is dermatan sulfate abundant?
skin and heart valves
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What GAG is abundant in skin and heart valves?
dermatan sulfate
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What GAG is abundant in lung and skin?
herparan
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The GAG heparin is abundant in what tissue?
lung and skin
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The GAG heparan sulfate is abundant in what tissue?
basal laminae
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What GAG is abundant in the basal laminae?
heparan sulfate
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What GAG is abundant in carnea, cartilage, interveterbral disc?
keratan sulfate
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In what tissue is the GAG keratan sulfate abundant?
cornea, cartilage, intervetebral disc
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is a matrix adhesive
glycoprotein, mediates cell-cell adhesion. Has many binding sites. Either
cell-surface fibronectin or plasma fibronectin- fibrin (blood clotting protein)
heparin (anti-clotting protein). Promotes healing by binding with fibril. Guide
immune cells to area.
fibronectin
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is secreted
by epithelial cells into the adjacent basal laminae. And external of muscle cells and Schwann
cells. binds cell surface
receptor, collagen IV, heparan sulfate, and entactin. It anchors the epithelia
cells to the basal lamina. Necessary for cell migration during embryotic
development. Mutation in (------)5 gene gives rise to epidermolysis bullosa
(blister).
laminin
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is part of the basement membrane, it links
laminin with collagen IV in the lamina densa.
entactin
-
plays a role in cell-matrix migration; it can promote or discourage cell adhesion cell-dependently.
It is secretd by glial cells in the developing nervous system and is abundant in embryonic
tissues.
tanascin
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Plays a role in development and maintenance of cartilage. It attaches collagen type II fibers to chondrocytes. It provides bindings to proteoglycans, collagens, and cell-surface receptors.
chondronectin
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They bind minerals to type I collagen in bones. They influence calcification by influencing crystal growth.
osteonectin
-
Is a family of transmembrane glycoproteins that binds to collagen, fibronectin, laminin, and ECM components. They act as cell surface receptors, that binds to extracellular ligans, which have RGD (arginin-glycine-aspartae sequence).
integrin
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What collagen is found in bone, dentin, tendon, dermis, scars, and organ capsules?
type 1 collagen
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Type 1 collagen is found in what tissue?
bone, dentin, tendon, dermis, scars, organ capsules
-
what collagen is found in hyaline and elastic cartilage, and vitreous in eye?
type 2 collagen
-
type 2 collagen is found in what tissue?
hyaline and elastic cartilage, vitreous in eye
-
what collagen is found in reticular fibers?
type 3 collagen
-
type 3 collagen is found in what tissue?
reticular fibers
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what collagen is found in the basal laminae and lens of the eye?
type 4 collagen
-
where is type 4 collagen found?
basal laminae and lens of eye
-
what collagen is found in fetal membranes and small vessels?
type 5 collagen
-
where is type 5 collagen found?
fetal membrane and small vessels
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the enzyme collagenases degrades what collagen?
type 1,2,3,10 collagens
-
type 1,2,3,10 collagens are degraded by what enzyme?
collagenase
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the enzyme matrilysin degrades what collagen?
type 4 collagen
-
type 4 collagen is degraded by what enzyme?
matrilysins
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the enzyme gelatinase degrades what collagen?
denatured collagen, laminin, firbonectin, elastin
-
denatured collagen, laminin, fibronectin, elastin are degraded by what enzyme?
gelatinase
-
the enzyme stomelysin degrades what collagen?
denatured collagen, proteoglycan, fibronectin
-
denatured collagen, proteoglycans, fibronectin are degraded by what enzyme?
stomelysin
-
What is osteogenesis imperfecta?
it is a genetic disorder caused by a type 1 collagen defect. It leads to fragile bones, which are prone for repeated fractures, teeth abnormalities, lax joint, and hearing loss
-
this genetic disorder is caused by type 1 collagen defect. It leads to fragile bones, which are prone for repeated fractures, teeth abnormalities, lax joints, and hearing loss.
osteogenesis imperfecta
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what is Ehlers Danlos syndrome?
it is a disease caused by type 3 collagen defect. symtoms include spontaneous arterial, intestinal, urinal rupture, hyperextensible and fragile skin, poor wound healing, easy bruising, pseudotumors, and joint hypermobility.
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it is a disease caused by type 3 collagen defect. symtoms include spontaneous arterial, intestinal, urinal rupture, hyperextensible and fragile skin, poor wound healing, easy bruising, pseudotumors, and joint hypermobility.
Ehlers Danlos syndrome
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what is Marfan syndrome
it is an autosomal dominant disorder caused by defects in the fibrillin-1 gene for glycoproteins that forms microfibrils. symtoms includ dissection at the base of aorta/ aortic aneurysm, long thin extremities, dislocation of lenses (ectopis lentis)
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it is an autosomal dominant disorder caused by defects in the fibrillin-1 gene for glycoproteins that forms microfibrils. symtoms includ dissection at the base of aorta/ aortic aneurysm, long thin extremities, dislocation of lenses (ectopis lentis)
Marfan syndrom
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