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_____ can be defined as the energy transformations that occur in living organisms, and the flow of that energy through these organisms.
Bioenergetics
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Biological energy transductions (transfers) are based on the _____.
First two laws of thermodynamics
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_____ is the energy of the universe is constant. This law refers to energy conservation. Energy does not change form.
First Law of Thermodynamics
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_____ says in any physical or chemical process, the amount of entropy tends to increase. This law states that no energy transformation process is 100% efficient. There is always some quantity of energy that is converted to a form that is no longer useful (lost as heat).
Second Law of Thermodynamics
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_____ can be defined as the extent of randomness or disorder in a system.
Entropy
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Natural systems are always moving towards a state of increasing entropy (theoretically, finally terminating in _____), and energy must be put into the system in order to stop the trend towards increased entropy.
Entropic doom
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The ability of a reaction to accomplish work is based on the principle of _____.
Free Energy
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_____ can be defined as the mean molecular kinetic energy of matter.
Temperature
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Temperature cannot be held constant when this thermal energy is given up, thus the lost thermal energy is considered _____-goes toward entropy increase.
Isothermally unavailable
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Reactions with a negative ΔG are known as _____ reactions, or energy yielding reactions.
Exergonic (spontaneous)
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Reactions with a positive ΔG are known as _____ reactions, or energy consuming/requiring reactions.
Endergonic
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At equilibrium, there will be _____ in the concentrations of reactants and products.
No net change
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The net free energy in coupling reactions must always be _____.
Negative
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Oxidation of a carbon atom in a carbon compound is synonymous with ______ (loss of hydrogen atoms bonded to carbon).
Dehydrogenation
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In cells, electrons can be transferred from one molecule to another in four different ways:
- 1. directly as electrons
- 2. as a hydrogen atom (1 electron & 1 proton)
- 3. as a hydride ion (2 electrons & 1 proton)
- 4. as a direct combination of an organic reductant with oxygen, producing a molecular product in which oxygen is covalently bonded
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Photosynthesis and respiration are primarily a sequence of electrochemical reactions, mostly consisting of a series of _____ and _____ reactions, or _____ reactions.
Oxidation and reduction
Redox
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Each redox reaction can be conveniently dissected into 2 half reactions involving the _____ and _____ of one or more electrons.
Donation and acceptance
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The electron donor becomes _____.
Oxidized
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The electron acceptor becomes ______.
Reduced
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A reduced/oxidized pair is known as a _____.
Redox couple
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The ability of a molecular species to accept electrons from, or donate electrons to another molecule, is known as its _____.
redox potential
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When a redox couple is 50% reduced, this is known as the _____.
Midpoint potential
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There are 4 primary reasons why ATP will spontaneously hydrolize into ADP and Pi:
- 1. electron repulsion amongst the four negative charges is somewhat relieved by charge separation after hydrolysis
- 2. inorganic phosphate (Pi) released by hydrolysis is stabilized by resonance hybride which does not allow H+ to bond to the oxygen atoms of Pi
- 3. ADP is also immediately ionized and releases a H+ ion into a high pH (7.0) solution
- 4. ADP and Pi have a higher degree of solvation (hydration) in water than does ATP; this further stabilizes products over reactants.
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Under conditions that define standard free energy change, the mass-action ration for ATP hydrolysis is _____ than equilibrium.
Five orders of magnitude less
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The maintenance of a steady-state system is known as _____.
Homeostasis
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ATP links _____ (breakdown of biomolecules into smaller precursors) and _____ (building of biomolecules in the cell.
Catabolism
Anabolism
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ATP is used primarily for the following processes:
- 1. synthesis of metabolic intermediates and macromolecules from smaller precursors (anabolism).
- 2. transport of substances across membranes against concentration gradients (active transport)
- 3. phosphorylation of biomolecules and group transfer reactions
- 4. energy storage
- 5. mechanical motion
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The exergonic reaction of ATP hydrolysis actually occurs as a _____ step process.
Two
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Phosphorylated compounds can have a high or low _____, depending of how effectively they can be used to phosphorylate other compounds.
Phosphate group transfer potential
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A group of enzymes known as _____ catalyze the phosphorylation of certain molecules by ATP.
Kinases
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The size and complexity of ATP allows it to form many more favorable _____ between itself and the substrate, over what would be possible with pyrophosphate (PPi).
Noncovalent interactions
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Many noncovalent interactions that are formed increased the _____ (energy derived from the formation of noncovalent interactions) and dramatically increase the rate of reaction.
Binding energy
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_____ is a electrostatic attraction between oppositely charged regions of water molecules, or between two molecules with polar covalent bonds.
Hydrogen bonding
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_____ is an electrostatic interaction between charged groups.
Ionic interaction
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_____ is attractive interactions between non-polar groups.
Hydrophobic interactions
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_____ are attractive forces between large, closely positioned molecules.
Van der walls forces
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