
cardiomegaly with apical atrophy is the classical finding in
Chaga's disease (Trypanosoma cruzi)

cellular crescents in Bowman's capsule is the classical finding in
rapidly progressive crescentic glomerulonephritis

chocolate cyst of ovary is the classical finding in
endometriosis (frequently involves both ovaries)

circular grouping of dark tumor cells surrounding pale neurofibrils is the classical finding in
HomerWright rosettes (neuroblastoma, medulloblastoma, retinoblastoma)

colonies of mucoid Pseudomonas in lungs is the classical finding in
cystic fibrosis (autosomal recessive mutation in CFTR resulting in fat soluble vitamin deficiency and mucous plugs)

decreased αfeto protein in amniotic fluid/maternal serum is the classical finding in
Down synd or other chromosomal abnormality

degeneration of dorsal column nerves is the classical finding in
Tabes dorsalis (tertiary syphilis), subacute combined degeneration (dorsal columns and lateral corticospinal tracts affected)

depigmentation of neurons in substantia niagra is the classical finding in
Parkinson's disease (basal ganglia disorder: rigidity, resting tremor, bradykinesia)

desquamated epithelium casts in sputum is the classical finding in
Curschmann's spirals (bronchial asthma;can result in whorled mucous plugs)

disarrayed granulosa cells in eosinophilic fluid is the classical finding in
CallExner bodies (granulosa  theca cell tumor of the ovary)

dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia is the classical finding in
koilocytes (HPV: predisposes to cervical cancer)

enlarged cells with intranuclear inclusion bodies is the classical finding in
"owl's eye" appearance in CMV

enlarged thyroid cells with ground glass nuclei is the classical finding in
"orphan Annie's eyes" nuclei (papillary carcinoma of the thyroid)

eosinophilic cytoplasmic inclusion in the liver cell is the classical finding in
Mallory bodies (alcoholic liver disease)

eosinophilic cytoplasmic inclusion in nerve cell is the classical finding in
Lewy body (parkinson's disease)

eosinophilic globule in liver is the classical finding in
Councilman body (toxic or viral hepatitis, often yellow fever)

eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells is the classical finding in
Negri bodies of rabies (Lyssavirus)

extracellular amyloid deposition in gray matter of brain is the classical finding in
Senile plaques (Alzheimer's disease)

Giant B cells with bilobed nuclei with prominent inclusions ("owl's eye") is the classical finding in
ReedSternberg (Hodgkin's lymphoma)

Glomerulus like structure surrounding vessel in germ cells is the classical finding in
SchillerDuval bodies (yolk sac tumor)

"hair on end" (crew cut) appearance on Xray is the classical finding in
β thalassemia, sickle cell anemia (marrow expansion)

hCG elevated is the classical finding in
Choriocarcinoma, hydatiform mole (occurs with and without embyo)

heart nodules (granulomatous) is the classical finding in
Aschoff bodies (rheumatic fever)

heterophile antibodies is the classical finding in
infectious mononucleosis (EBV)

hexagonal, douglepointed, needle like crystals in bronchial secretions is the classical finding in
Bronchial asthma (CharcotLeyden crystal: eosinophilic granules)

high level of Ddimers is the classical finding in
DVT, pulmonary embolism, DIC

hilar lymphadenopathy, peripheral grnaulomatous lesion in middle or lower lung lobes (can calcify) is the classical finding in
Ghon complex (primary TB: mycobacterium bacilli)

"Honeycomb lung" on X ray or CT is the classical finding in
interstitial pulm fibrosis

hypercoagulability (leading to migrating DVTs and vasculitis) is the classical finding in
Trousseau's synd (adenocarcinoma of pancreas or lung)

hypersegmented neutrophils is the classical finding in
megloblastic anemia (B12 deficiency: neurologic symp; folate deficiency: no neurologic symp)

hypertension, hypokalemia, metabolic alkalosis is the classical finding in
Conn's synd

hypochromic, microcytic anemia is the classical finding in
Fe deficiency anemia, lead poisoning, thalassemia (fetal Hb sometimes present)

increase alpha fetoprotein in amniotic fluid/maternal serum is the classical finding in
Dating error, anencephaly, spina bifida (neural tube defects)

increased uric acid levels is the classical finding in
Gout, LeschNyhan synd, tumor lysis synd, loop and thiazide diuretics

intranuclear eosinophilic droplet like bodies is the classical finding in
Cowdry type A bodies (HSV or CMV)

Fe containing nodules in alveolar septum is the classical finding in
Ferruginous bodies (asbestosis: inc chance of mesothelioma)

keratin pearls on a skin biopsy is the classical finding in
squamous cell carcinoma

large lysosomal vesicles in phagocytes, immunodeficiency is the classical finding in
ChediakHigashi disease (congenital failure of phagolysosome formation)

"Lead pipe" appearance of colon on barium enema X ray is the classical finding in
Ulcerative colitis (loss of hustra)

Linear appearance of IgG depositon on glomerular basement memb is the classical finding in
Goodpasture's synd

low serum Ceruloplasmin is the classical finding in
Wilson's disease (hepatolenticular degeneration)

"lumpy bumpy" appearance of glomeruli on immunofluorescence is the classical finding in
post streptococcal glomerulonephritis (immune complex deposition of IgG and C3b)

Lytic ("hole punched") bone lesions on X ray is the classical finding in
Multiple myeloma

mammary gland ("blue domed") cyst is the classical finding in
fibrocystic change of breast

Monoclonal antibody spike is the classical finding in
 Multiple myeloma (usually IgG or IgA)
 monoclonal gammopathy of undetermined significance (MGUS; normal consequence of aging)
 Waldenstrom's (M protein=IgM) macroglobulinemia
 primary amyloidosis

mucin filled cell with peripheral nucleus is the classical finding in
Signet ring (gastric carcinoma)

narrowing of bowel lumen on barium X ray is the classical finding in
"String sign" (Crohn's disease)

necrotising vasculitis (lungs) and necrotising glomerulonephritis is the classical finding in
Granulomatosis with polyangitis (Wegner's; cANCA positive) and Goodpasture's synd (antibasement memb antibodies)

needle shaped, negative birefringent crystals is the classical finding in
Gout (monosodium urate crystals)

nodular hyaline deposits in glomeruli is the classical finding in
KimmelstielWilson nodules (diabetic nephropathy)

Novobiocin response is the classical finding in
 sensitive: Staphylococcus epidermidis;
 resistant: Staphylococcus saprophyticus

"Nutmeg" appearance of liver is the classical finding in
chronic passive congestion of liver due to right heart failure

"Onion skin" periosteal reaction is the classical finding in
Ewing's sarcoma (malignant round cell tumor)

Optochin response is the classical finding in
 sensitive: Streptococcus pneumoniae
 resistant: Viridans streptococcus

periosteum raised from bone, creating triangular area is the classical finding in
Codman's triangle on X ray (osteosarcoma, Ewing's sarcoma, pyogenic osteomyelitis)

podocyte fusion or "effacement" on electron microscopy is the classical finding in
Minimal change disease (child with nephrotic synd)

Polished, "ivory like" appearance of bone at cartilage erosion is the classical finding in
Eburnation (osteoarthritis resulting in bony sclerosis)

protein aggregates in neurons due to hyperphosphorylation of protein tau is the classical finding in
Neurofibrillary tangles (Alzheimer's disease) and Pick's bidies (Pick's disease)

psammoma bodies is the classical finding in
meningiomas, papillary thyroid carcinoma, mesothelioma, papillary serous carcinoma of endometrium and ovary

Pseudopalisading cells on brain biopsy is the classical finding in
Glioblastoma multiforme

RBC casts in urine is the classical finding in
Acute glomerulonephritis

rectangular, crystal like, cytoplasmic inclusions in Leydig cells is the classical finding in
Reinke crystals (Leydig cell tumor)

renal epithelial casts in urine is the classical finding in
Acute toxic/viral nephrosis

rhomboid crystals, positively birefringent is the classical finding in
Pseudogout (calcium pyrophosphate dihydrate crystals)

rib notching is the classical finding in
coarctation of aorta

ring enhancing brain lesion in AIDS is the classical finding in
Toxoplasma gondii, CNS lymphoma

sheets of medium sized lymphoid cells with scattered pale, tingible bodyladen macrophages ("starry sky" histology) is the classical finding in
Burkitt's lymphoma (t[8:14] cmyc activation, associated with EBV; "black sky" made up of malignant cells)

silver staining spherical aggregation of tau proteins in neurons is the classical finding in
Pick's bodies (Pick's disease: progressive dementia, changes in personality)

"soap bubble" in femur or tibia on X ray is the classical finding in
Giant cell tumor of bone (generally benign)

"spikes" on basement memb, "dome like" subepithelial deposits is the classical finding in
membranous glomerulonephritis (may progress to nephrotic synd)

