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Homeostasis
- conditions that keep the body as normal as possible.
- Keeping the body in balance
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Homoeostatic mechanisms
Control mechanisms to prevent changes in body that deviate from normal
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Extracellular fluid
the fluid outside the cells (1/3 of body water), includes interstitial space, blood, lymph, done, and connective tissue water.
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Intracellular fluid
fluid inside the cells (2/3 of body water)
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Interstitial space
included in the ECF, fluid between cells, sometimes called the third space
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Transcellular fluids
are the fluids in special body spaces and include cerebrospinal fluid, synovial fluid, peritoneal fluid, and pleural fluid.
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Solvent
water portion of fluids
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Solute
are the particles dissolved or suspended in water
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Filtration
- movement of fluid through a cell or blood vessel membrane because of hydrostatic pressure differences on both sides of the membrane.
- Occurs because of differences in water volume pressing against the confining walls of the space.
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Hydrostatic pressure
pressing of water molecules against the confining walls (water pushing pressure, it is the force that pushes water outward from a confines space through a membrane)
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Equilibrium
hydrostatic pressure is the same in both fluid spaces
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Disequilibrium
hydrostatic pressure not the same on both sides
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Gradient
graded difference (one space has a higher hydrostatic pressure than the other)
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Edema
tissue swelling with fluid collection in third space
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Diffusion
free movement of particles (solute) across a permeable membrane from an area of higher concentration to an area of lower concentration (down a concentration gradient)
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Impermeable
Membranes not open to certain particles
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Facilitated diffusion (facilitated transport)
diffusion across a cell membrane that requires the assistance of a membrane-altering system
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Osmosis
movement of water only through a selectively permeable (semi-permeable) membrane
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Osmolarity
the number of milliosmoles in a liter of solution
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Osmolality
is the number of milliosmoles in a kg of solution
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Isotonic (isosmotic/normotonic)
when all body fluids have the same gradient
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Hypertonic (hyperosmotic)
fluid with osmolarities greater than 300 mOsm/L, they have greater osmotic pressure
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Hypotonic( hypo-osmotic)
fluids with osmolarities of less than 270 mOsm/L, they have lesser osmotic pressure
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Solubility
how well a particle type dissolves in water.
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Lymph
fluid similar to flood plasma, but contains far less protein
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Obligatory urine output
the minimum amount of urine per day needed to excrete toxic waste products is 400-600m
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Insensible water loss
water loss from the skin, lungs, and stool
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Aldosterone
hormone secreted by the adrenal cortex whenever sodium level in the ECF is decreased. Prevents both water and sodium loss
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ADH
or vasopressin, acts directly on kidney tubules and collecting ducts making them more permeable to water. More water is reabsorbed
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Natriuretic peptides
hormones secreted by special cells that line the atria of the heart and ventricles of the heart. They are secreted in response to increased blood volume and BP. Have effects opposite of aldosterone
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Dehydration
fluid intake is less than what is needed to meet the body’s fluid needs, resulting if a fluid volume deficit.
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Hypovolemia
circulating blood volume is decreased and leads to inadequate tissue perfusion
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Orthostatic Hypotension
hypotension is more severe with the patient in a standing position than with the patient in the sitting or lying position
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Hypoxia
body has decreased oxygen levels
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Hemoconcentration
increased osmolarity or concentration of the blood
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Fluid overload (overhydration)
excess of body fluid
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Hemodilution
excessive water in the vascular space
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Electrolytes (ions)
are substances in body fluids that carry an electrical charge
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Sodium (Na+)
a mineral, is the major cation in the ECF and maintains ECF osmolarity
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Hyponatremia
is a serum sodium level below 136. Often occur with fluid volume imbalances because the same hormones regular both sodium and water balance
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Hypervolemia
fluid overload
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Hypernatremia
serum sodium level over 145
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Excitability
more sodium is present to move readily across cell membranes during depolarization, making excitable tissues more easily excited.
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Hypokalemia
is a serum potassium level below 3.5
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Hyporeflexia
decreased response to deep tendon reflex stimulation
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Paralytic Ileus
absence of peristalsis
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Hypoxemia
decreased blood oxygen levels
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Hypercapnia
increased arterial carbon dioxide levels
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Hyperkalemia
serum potassium level higher than 5.0
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Ectopic beats
as serum potassium levels rise, heartbeats generated outside the normal conduction system in the ventricles
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numbness in hands and feet and around the mouth
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Divalent cation
having two positive charges (Ca2+)
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Hypocalcemia
total serum calium level below 9.0 mg/dl or 2.25 mmol/L
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Hypercalcemia
a total serum calcium level about 10.5mg/dl or 2.75mmol/L
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Hypophosphatemia
a serum phosphorous level below 3.0 mEq/L
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Rhabdomyolysis
weak skeletal muscle that progresses to acute muscle breakdown
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Hyperphosphatemia
serum phosphorous level above 4.5 mEq/L
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Magnesium (Mg2+)
mineral that forms a cation when dissolved in water
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Hypomagnesemia
serum magnesium level below 1.3 mEq/L
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Hpyermagnesemia
a serum magnesium level about 2.1 mEq/L
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Infusion Therapy
delivery of parenteral medications and fluids through a wide variety of catheter types and locations using multiple procedures
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Infusate
solution that is infused into the body
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Adverse drug events (ADE)
immediate serious reactions
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Vascular access device (VAD)
plastic tube placed in a blood vessel to deliver fluids and medications
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Peripheral IV Therapy
IV medications given in veins
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Short Peripheral Catheters
composed of plastic cannula built around a sharp stylet extending slightly beyond the cannula.
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Midline Catheters
are 6-8 inches long and are inserted through the veins of the antcubital fossa
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Vesicant Medications
drugs that cause severe tissue damage if they espace into the subcutaneous tissue
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Extravasation
leaving into the subcutaneous tissue
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Central IV Therapy
the VAD is placed in the central blood vessels, such as the superior vena cava
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Nontunneled percutaneous central catheters
inserted by a physician through the subclavian vein in the upper chest or the jugular veins in the neck using sterile technique.
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Tunneled cetral venous catheters
have a portion of the catheter lying in a subcutaneous tunnel, separating the points where the catheter enters the vein from where it exits the skin
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Implanted ports
consist of a portal body, a dense septum over a reservoir, and a catheter
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Huber needles
noncoring port access needles
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Piggyback set (second administration set)
attached to the primary set at a Y-injection site and is used to deliver intermittent medications.
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Controller
- stationary, pole-mounted electronic device that uses a sensor to monitor fluid flow and to deter when flow has been interrupted.
- Rely completely on gravity create fluid flow.
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Pumps
pump medication or fluid under pressure
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Syringe pumps
use an electronic or battery powered piston to push the plunger continuously at a selected milliliter-per-hour rate
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Ambulatory pumps
generally use for home care patients and allow them to reutn to their usual activities which receiving infusion therapy.
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Intraperitoneal (IP) Therapy
the administration of chemotherapy agents into the peritoneal cavity
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Hypodemoclysis
involves the slow infusion of isotonic fluids into the patient’s subcutaneous tissue
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Epidural
space between the dura mater and the vertebrae
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Subarachnoid
below the arachnoid space
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Intrathecal
infused into the subarachnoid space closer to the spinal cord
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Intraosseous (IO) Therapy
allows access to the rich vascular network located in the long bones
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Compartment syndrome
- condition in which increase tissue pressure in a confined anatomic space causes decreased
- blood flow to the area.
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Preoperative
Before surgery
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Intraoperative
During surgery
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Postoperative
After surgery
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Inpatient
a patient who is admitted to a hospital
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Outpatient and Ambulatory
patient who goes to the surgical area the day of the surgery and returns home the same day
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Carboxyhemoglobin
carbon monoxide on oxygen binding sites of the hemoglobin molecule
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Atelectasis
collapse of alveoli
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Autologous donations
patient donates own blood before scheduled surgery
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Morbidity
serious problems
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Dyuria/disuia
painful urination
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Nocturia
awakening during nighttime sleep because of a need to void
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Oliguria
scant amount of urine, difficult to urinate
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NPO
no eating, drinking, smoking (stimulates gastric secretions)
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Laser
high powered beam of light that cuts tissue more cleanly than do scalpel blades (Light Amplification by the Stimulated Emission of Radiation)
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Endoscope
a tube that allows viewing and manipulation of internal body areas
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Insufflation
the act of injecting of gas or air into the cavity before the surgery to separate organs and improve visualization.
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Anesthesia
induced state of partial or total loss of sensation,occuriring with or without loss of consciousness. Anesthesia blocks nerve impulse transmission, suppress reflexes, promote muscle relaxation and controlled level of unconsciousness
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Analgesia
pain relief or pain suppression
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Amnesia
memory loss of the surgery
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Emergence
recovery from the anesthesia
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Myoglobinuria
presence of muscle proteins in urine
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Local anesthesia
applied to the skin or mucous membranes of the area to be anesthetized
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Regional anesthesia
blocks multiple peripheral nerves in a specific body region
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Autologous blood
transfusion
reinfusing the patient’s own blood
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Absorbable sutures
sutures that are digested over time by body enzymes
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Nonabsorable sutures
encapsulated in the tissue during the healing process and remain in tissue until removed
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Postanesthesia care unit
(PACU)
recovery room
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Pulse deficit
difference between the apical and peripheral pulses
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Dehiscence
- partial or complete separation of the outer wound layers
- “splitting open of the wound”
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Evisceration
total separation of all wound layers and protrusion of internal organs through the open wound
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Debridement
removal of the infected or dead tissue
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