Haloperidol (Haldol)

  1. Trade Name
  2. Class
    Tranquilizer, Antipsychotic
  3. Mechanism of Action
    Inhibits central nervous system (CNS) catecholamine receptors: strong antidopaminergic and weak anticholinergic. Acts on CNS to depress subcortical areas, mid-brain and ascending reticular activating system in the brain.
  4. Indications
    Acute psychotic episodes
  5. Contraindications
    Agitation secondary to shock or hypoxia. Hypersensitivity
  6. Adverse Reactions
    Extrapyramidal signs and symptoms, restlessness, spasms, Parkinson-like symptoms, drooling, dystonia, hypotension, orthostatic, hypotension, nausea, vomiting, blurred vision.
  7. Drug Interactions
    Enhanced CNS depression and hypotension in combination with alcohol. Antagonized amphetamines and epinephrine. Other CNS depressants may potentiate effects.
  8. How Supplied
    5 mg/ml ampule.
  9. Dosage and Administration
    • Adult: 2-5 mg IM every 30-60 minutes until sedation achieved.
    • Pediactric: Not recommended.
  10. Duration of Action
    • Onset: 10 minutes.
    • Peak Effect: 30-45 minutes.
    • Duration: variable (generally 12-24 hours).
  11. Special Considerations
    Pregnancy safety: not established. Treat hypotension secondary to Haldol with fluids and norepinephrine, not epinephrine. Patient may also be taking Cogentin (benztropine mesylate) if on long-term therapy with Haldol.
Card Set
Haloperidol (Haldol)
Paramedic Pharmacology