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bethanechol
- muscarinic agonist
- - ACh analog resistant to degradation by AChE and BChE
- - used for GI stasis and urinary retention
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pilocarpine
- muscarinic agonist
- - tertiary amine --> gets into CNS
- - used in ophthamology to treat glaucoma and sjogren's syndrome
-
atropine
- muscarinic antagonist
- - blocks ACh through competitive inhibition
- - tertiary amine --> helps with parkinsons
- - dec salivation and sweating
- - to treat cholinesterase poisoning, and emergency care for heart
-
tropicamide
- muscarinic antagonist
- - works like atropine but with shorter half life
- - used for mydriasis (dilate pupil) in eye exam
-
tolterodine
- muscarinic antagonist
- - like atropine but with M3 receptor preference
- - used to treat urge incontinence by dec urinary tract motility and voiding
-
tiotropium
- muscarinic antagonist
- - like atropine but a quaternary compound
- - inhaled to help with COPD and asthma (by inc bronchodilation and dec secretions)
-
physostigmine
- acetylcholinesterase inhibitor
- - indirectly increases parasymp effect
- - reversible by slow hydrolysis
- - tertiary amine
- - used for glaucoma acute attacks and to counter poisoning by anti-muscarinic agents
-
donepezil
- acetylcholinesterase inhibitor
- - indirectly inc parasymp effects
- - reversible competitive antagonist
- - tertiary amine, longer lasting
- - used for alzheimers
-
neostigmine
- acetylcholinesterase inhibitor
- - indirectly inc parasym effects
- - reversible by slow hydrolysis
- - quaternary amine; selectivity for NMJ action
- - used for relieving abdominal distension (inc motility and voiding)
-
sarin
- acetylcholinesterase inhibitor
- - indirectly inc parasymp effects
- - irreversible organophasphate
- - ex: nerve gas and insecticides
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