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Clinical Pharmacology
the study of drugs in humans
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Drug
any chemical that can affect living processes
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Pharmacology
the study of drugs and their interactions with living systems
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Therapeutics(pharmacotherapeutics)
the use of drugs to diagnose, prevent or treat disease or to prevent pregnancy; (medical use of drugs)
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Airborne Transmission
passage of microorganisms suspended in the air on water droplets or dust particles that enter the host by inhalation.
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Antibody
immunoglobin produced by the body in response to a specific antigen
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Antigen
forgeign material, usually a bacteria capable of inducing a specific immune response.
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Asepsis
absence of disease producing microorganisms; being free of infection
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Body Substance Isolation
technique based upon the premise that all body substances may contain pathogens. Never touch with the bare hand anything wet that comes from the body cavity.
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Carrier
person or animal who is without signs of illness but who have pathogens on or within body that can be transferred to others.
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Colonization
growth of microorganisms in or on the body. The presence and multiplication of microorganisms without tissue invasion or damage. The infected individual shows no signs or symptoms of infection, while the potential to infect others still exists.
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Contact Transmission
physical transfer of an organism between an infected or colonized person and a susceptible host involving direct or indirect contact.
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Convalescent period
stage of an infection that represents recovery from the infection.
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Disinfectant
substance, usually intended for use on inanimate objects, that destroy pathogens, but generally not spores.
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Droplet
inhalation of respiratory pathogenic microorganisms suspended on
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Transmission
liquid particles exhaled by someone already infected
ex. a person suffering from an upper respiratory infection sneezes, allowing the microorganism to exit the body and inhaled by another person.
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Enodenous
infection in which the causative(cause) organisms comes from microbial life the person itself harbors.
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Full Stage of Illness
stage of an infection characterized by the presence of specific signs and symptoms.
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Immune response
specific reactions in the body as it response to an invading foreign protein such as bacteria, of even in some cases the bodys own protein.
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Incubation period
stage of infection between exposure to an infectious organism and the appearance of clinical systems of disease.
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Inflammatory Response
Localized response of the body to injury or the infection; protective mechanism that eliminates invading pathogens and allow for tissue repair to occur.
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Medical Asepsis
techniques used to control and to reduce the spread of pathogenic microorganisms. A medical aseptic technique is hand washing.
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Reservoir
place where microorganisms can thrive and reproduce.
ex. humans,animals,and inanimate objects, such as water,tabletops and doorknobs.
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Resident bacteria
microorganisms that normally live on a person's skin.
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Systemic symptoms
symptoms manifested throughout the entire body.
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Transient Bacteria
microorganism picked up on the skin as a result of normal activities, which can be removed readily.
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Vehicle Transmission
transfer of microorganisms by way of contaminated items.
ex. blood can carry hep and HIV
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virulence
ability to produce disease
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VRE
- organism that resists the effects of the antibiotic Vancomycin. For many patients infected with There is no known effective medication. is one of the common causes of nosocomial infection and is easily transmitted on the hands of the health care worker.
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Adventitious sounds
abnormal breath sounds heard over the lung
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Antipyretic
agent that reduces fever
ex. aspirin
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Apnea
absence of breathing
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Arrythmia
irregular pattern of heart beat
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Ausculatory
listening for sounds within the body
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Ausculatory Gap
Temporary disappearance of the Korotkoff sounds, it typically occurs between the 1st and 2nd sounds
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Biots respiration
Respirations of the same depth followed by a period of apnea
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Blood pressure
force of blood against the artery walls
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Bradycardia
abnormally slow rate of pulse; <60 BPM
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Cardinal signs
temperature, pulse, respiratory rates and blood pressure
AKA- vital signs
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Cheyne-Stokes respiration
gradual increase and the gradual decrease in depth of respirations followed by a period of apnea.
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Circadian rhythm
rhythm that completes a full cycle every 24 hours;
diurnal rhythm
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Conduction
transfer of heat to another object during direct contact
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Convection
dissemination of heat by motion between areas of unequal density the body
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Core temperature
temperature of internal areas of the body
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Dyspnea
difficult breathing
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Dysrhythmia
irregular pattern of heartbeat; synonym is arrhythmia
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Essential hypertension
abnormally elevated blood pressure with no known cause.
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Eupnea
normal respirations
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External respiration
act of lung ventilation, oxygen absorption and carbon dioxide elimination
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Exhalation
act of breathing out
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Friction rub
crackling sound heard in the chest cavity, caused by inflamed pleura rubbing against the chest wall.
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Hyperpyrexia
high fever, above 105.8
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Hypertension
blood pressure elevated above the upper limit of normal
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Hypotension
blood pressure below the lower limit of normal
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Inhalation
act of breathing in
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Intermittent fever
body temperature that alternates between a period of fever and a period of normal or subnormal temperature
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Internal respiration
act of using oxygen by body cells.
tissue respiration
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Korotkoff sounds
series of sounds that correspond to changes in blood flow through an artery as pressure is released
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Lysis
gradual return of an elevated body temperature to normal
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Orhopnea
type of dyspnea in which breathing becomes easier when the patient sits or stands
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Orthostatic hypotension
temporary fall in blood pressure associated with assuming an upright position
postural hypotension
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Palpitation
perception of ones own heartbeat
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peripheral resistance
restraint to blood flow created by arterial walls in a partial state of contraction
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Polypnea
Fast respiratory rate
Tachypnea
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Premature beat
irregular rhythm in which a heartbeat occurs sooner that the pace at which previous ones were noted
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Primary hypertension
abnormally elevated blood pressure with no known cause
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Pulse deficit
difference between the apical and radial pulse rates.
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Pulse pressure
difference between the systolic and diastolic pressures
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Pyrexic
elevation above the upper limit of normal body temperature.
aka fever
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Relapsing fever
abnormal lung sound that returns to normal for at least a day after which fever returns
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Rales/Crackles
abnormal lung sounds described as crackling in nature
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Remittent fever
body temperature that fluctuates several degrees above normal, but does not reach normal between fluctuations
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Rhonchi/Sonorous wheeze
abnormal continuous sound characterized by a characterized by a sonorous, dry, coarse sound heard over the large airway.
can be cleared with a cough
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Set point
the level at which the hypothalamus attempts to maintain body temperature
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Stertorous breathing
noisy respirations
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Stridor
harsh, high-pitched sound usually heard on inspiration when upper airways become narrowed
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Tachycardia
abnormally rapid rate; >100 BPM
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Wheeze
continuous, high-pitched sound heard over the small bronchial tubes.
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