Innate Immunity

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  1. Two main responses 
    Innate Immunity
    are Inflammation and antiviral defense
  2. does Innate immunity  react agains
    host (autoimmunity)?
    • Innate immunity does not react agains
    • host (autoimmunity
  3. Innate immunity instructs adaptive immunity to respond to microbes

    •3 main Components
    • 1.Barriers
    • 2.Cells which recognize microbial products
    • 3.Circulating soluble proteins with antimicrobial activity
  4. 2 types of Barriers and examples
    • 1.Physical/Anatomical barrier:
    • skin and mucus membranes

    • 2.Chemical/Physiological barriers:
    • Acidity of stomach, soluble molecules with antimicrobial
    • property
  5. •first line of defense against infection
    Skin and mucus membranes
  6. name 2 Antimicrobial peptides
    • Defensins
    • Cathelicidins
  7. Defensin:
    1. alpha-->
    2. Beta -->
    3. panet -->
    • 1. skin
    • 2. resp
    • 3. GI
  8. which cells are producing defensins
    • neutrophils,
    • NK cells,
    • cytotoxic T cells
  9. which cells are producing cathelicidins and how production will be stimulated
    • epithelia
    • and neutrophils
    • •Production stimulated by inflammatory cytokines and microbial products
  10. Second line of defense

    •Cellular defense mechanisms

    • •Soluble proteins and defense (complement
    • components)
  11. what discriminates between self (host) and non self (pathogen)
    Molecular sensors
  12. MAJOR
    • 1. neutrophils
    • 2. macrophages 
    • 3. dendritic cells
    • 4. NK cells
  13. what are the patterns on pathogens are called
    •pathogen associated molecular patterns (PAMPs)
  14. what are the receptors pf PAMPs called
    •Pattern recognition receptors (PRRs) and
  15. PRRs expressed by
    • NK cells,
    • macrophages and
    • neutrophils
  16. what are PRMs (pathogen recognition molecules)
    • •PRMs are soluble
    • free floating proteins
    • that may activate complement (mannose binding lectin MBL, C reactive protein; CRP) or act as opsonins
  17. what is the Ability of PRR and PRM
    • •to distinguish self from non self flaw less ( pattern only on pathogens)
    • •Also
    • recognize damage associated molecular patterns released from damaged or necrotic
    • cells (DAMP)
  18. what are the Structures or ligands recognized by
    • Lipoteichoic acid of
    • gram positive bacterial cell wall

    • Lipopolysacharide (endotoxin)
    • of
    • gram negative bacterial cell wall

    Bacterial flagella protein flagellin

    Bacterial DNA with unmethylated 

    Viral ds RNA ;ss RNA
  19. what are Toll like receptors (TLR)
  20. Pathogenrecognition receptors PRRs
  21. Toll like receptors (TLR) types
    • surface receptors,
    • intracellular, or
    • located on endosome membranes
  22. receptors of the innate immune system 
    just know the names
    • -complement (blood stream, tissue fluid) 
    • -mannose-binding lectin (MBL)(blood stream, tissue fluid) 
    • -C-reactive protein (CRP)(blood stream, tissue fluid) 
    • -Lipopolysaccharide (LPS) receptor; LPS-binding protein (LBP)(blood stream, tissue fluid) 
    • -TLR (cell surface or internal)
    • -NOD receptor(interacellular)
    • -Scavenger receptor (RRs)
Card Set
Innate Immunity
Innate Immunity
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