Alteplase Recombinant

fibrinolyctic

promotes fibrinolysis by forming the active proteolytic enzyme plasmin. plasmin in turn degrades fibrin fibrinogen and the clot

fribrinolysis in acute MI acute ischemic shock PE events

• internal bleeding
• AAA
• ICP
• hemorrhagic stroke within the past 6months
• uncontrolled hypertension

• internal bleeding
• superficial bleeding
• hemorrhagic hypertension

• MI/CVA
• 15mg IV followed by 0.75 mg/kg over 30min. max of 50mg then provide 0.5mg/kg over 60mins max of 35mg

• pulmmonary embolism
• 100mg IV infusion over 2hrs.