PHM112 Week 1&2

  1. What is the study of drugs?
  2. What is the study of the process of absorption, distribution, metabolism, and excretion?
  3. What is the measure of strength, or concentration of a drug to produce a specific effect?
  4. What is the percentage of drug that is actually absorbed into the blood stream?
  5. What are harmful, unintended effects?
    Adverse effects
  6. What mild reaction includes rash, urticaria (hives), or mild fever?
    Allergic hypersensitivity
  7. Includes sudden onset of dyspnea, chest constriction, shock and collapse?
    Severe reaction (anaphylaxis)
  8. What are the four drug sources?
    Plants, animals, chemical, and minerals
  9. What is effected by the following?

    pH, Presence/Absence of food, Lipid solubility, and drug formulation
  10. What is effected by the following?

    Protein Plasma Binding, Blood flow, Blood brain barrier, Metabolism, Elimination
  11. Without known cause?
  12. Relatively severe symptoms, but only lasts a short time?
  13. What are the key issues in Anti-infective selection?
    • Status of hepatic and or renal function
    • Age of patient
    • Pregnancy¬†
    • Likelihood of organism developing resistance
  14. What are antimicrobial resistances
    • Overuse or misuse
    • Prescribed without specific diagnosis
    • Patient does not complete drug therapy
  15. What are the common types of Gram Positive Cocci?
    Staphylococcus aureus - present on skin
  16. What 4 groups are common gram negative pathogens?
    Enteric, Haemophilus influenza, Neisseria, Pseudomonas
  17. What do cell wall inhibitors do?
    Kill bacteria by preventing synthesis or repair of the cell wall.
  18. What is the cell wall inhibitor class?
  19. What are the Protein Synthesis Inhibitor Classes?
    • Aminoglycoside (bactericidal)
    • Tetracycline (Bacteriostatic)
  20. What is effective against a variety of bacteria including most gram-positive organisms?
  21. What is the MOA of penicillin?
    Cell wall inhibitor and destroy bacteria
  22. Penicillin is the drug of choice for?
    Respiratory infections, Otitis media, venereal diseases
  23. What are the warnings of Penicillin?
    Acids in fruit juice can deactivate drug
  24. What are 2 specific Penicillin drugs?
    • Procaine Penicillin G (IM only)
    • Penicillin G Benzathine (IM only)
  25. What is a narrow spectrum - penicillinase resistance?
  26. What are some broad spectrum amino penicillin's?
    Amoxicillin, Amoxicillin/Clavulanate, Ampicillin/Sulbactam
  27. What are the extended spectrum, anti-pseudomonas Penicillins?
    Carbenicillin, Piperacillin, Piperacillin/Tazobactam, Ticarcillin, Ticarcillin/Clavulanate
Card Set
PHM112 Week 1&2
PHM112 Week 1&2