-
megaloblast
unsually large rbc caused by folate or vb12 deficiency
-
thalassemia
production of Hb molecyle affected
-
g6pd deficiency
- rbc metabolism problem
- hemolytic anemia
- gluththione protects from radicals
-
Is iron directly involved in RBC production?
no, folate/b12 erythpoeitin
-
reticulocytosis
Reticulocytosis is a condition where there is an increase in immature red blood cell, seen in anemia. They are seen on blood films when the bone marrow is highly active
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hemolytic anemia
- jaudice
- reticulocytosis
- sickle cell
- G6PD deficency
- pyrimidine nuclease deficiency
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who is the dentst concerned about?
- leukopenia
- leukemia, lymphoma
-
neutophil count
- less than 1500 bad
- less than 1000 infection
-
chemo patient when to treat
- treat before chemo
- treat at free intervals
-
aPTT partial thromboplastin time measures
factor 8
-
PT time (12-14 sec) measures
factor 7
-
INR
compares one lab results to another
-
platlet count normal
- 150-300k
- thrombocytopenia less than 100k
- more than 50k needed for surgery
-
congenital platlet disease(vW)
- vW disase, imparing of platelet adhesion
- administer demopressin, alphanate viral inactivaated factor 8-vW
-
antifibrinolytics
- inhibit plasminogen activation
- administer prior to surgery and 5d post-op
-
vW disease dont give
NSAIDs, aspirin
-
pavix/clopidogrel,, prasugrel, aspirin
do not discontinue for routine oral surgery
-
hemophillia(x-linked)
manage via factor replacement and aspirin
-
coumadin
- anticoagnulant, comp antagonist for vitamin K
- some INRs require this for DVT, A-fib
-
dental surgery injection extration with INR<3 on coumadin
if INR level is confirmed, OK
-
multiple teeth, INR, less or equal 1.5
consult doctor
-
oral factor 10a inhibitors
blocks clot
-
normal INR levels
0.8-1.2, higher on anticoagulants
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