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Direct Factor Xa inhibitors
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direct factor Xa inhibitor drugs:
Rivaroxaban
MOA:
directly inhibit the conversion of prothrombin to thrombin without using antithrombinIII as an intermediary
indication:
Postsurgical VTE prophylaxis ·
As an alternative to heparins in patients with severe HIT
Dose for Rivaroxaban:
Initial
:
15-20 mg po daily for 3 weeks
–
on exam (20 mg)
CI:
active bleeding
Pregnancy
pts at increased risk of bleeding
SE:
bleeding
DI:
Metabolism is via CYP450 3A4 enzymes
It is a substate of P-glycoprotein (Pgp)
There are no monitoring requirements
Author
merazar15
ID
228595
Card Set
Direct Factor Xa inhibitors
Description
pharm- direct factor Xa inhibitors
Updated
2013-07-30T13:41:29Z
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